44例胃肠间质瘤临床病理分析.docVIP

精品论文 参考文献 44例胃肠间质瘤临床病理分析 江苏泰兴市人民医院 病理科 225400 摘要：目的：探讨胃肠道间质瘤的临床病理特征及免疫组化特点。方法：复习44例胃肠道间质瘤临床资料，观察肿瘤组织学形态及其免疫表型。结果：44例胃肠道间质瘤中，男23 例，女21例，平均年龄55.2 岁，临床多表现腹痛、腹胀，消化道出血，腹部包块等。肿瘤细胞由梭形细胞和上皮样细胞组成。免疫组化表型：CD117 阳性37例，CD34 阳性34例，DOG-1阳性35例，Ki-67 阳性7例，。结论：GIST 可发生于全消化道，最常见发生于胃和小肠，其次是结直肠，食管占，极少数可发生于肠系膜、腹膜后。CD117、CD34及DOG-1 阳性表达是确诊GIST最有价值依据。GIST 的临床风险程度与肿瘤大小，核分裂象数密切相关。 关键词：胃肠道间质瘤；免疫组化；CD117；CD34；DOG-1 Objective：To investigate the clinical and pathological characteristics of gastrointestinal stromal tumor and its immunohistochemical features.Methods：the clinical data of 44 cases of gastric stromal tumor were reviewed，and the histological morphology and the immune phenotype were observed.Results：among the 44 cases，23 were male and 21 were female.The average age was 55.2 years old.The clinical manifestations were abdominal pain，abdominal distension，gastrointestinal bleeding，abdominal mass，and so on.Cells from the spindle cells and epithelioid cells.CD117 positive in 37 cases，CD34 positive in 34 cases，DOG-1 positive in 35 cases，Ki-67 positive in 7 cases，.Conclusion：GIST can occur in the whole digestive tract，most commonly occurred in the stomach and the small intestine，followed by colorectal，esophageal，very few can occur in the mesenteric and retroperitoneal.The positive expression of CD117，CD34 and DOG-1 was the most valuable basis for the diagnosis of GIST.The clinical risk of GIST is closely related to tumor size and mitotic figures. Keywords：gastrointestinal stromal tumor；immunohistochemistry；CD117；CD34；DOG-1 胃肠道间质瘤（GIST）GIST 起源于胃肠道间叶细胞的肿瘤[1]，在消化道间叶源性肿瘤中，最为常见。GIST 可发生在消化道从食管到直肠的任何部位，极少数可发生在消化道以外的部位。结合我院2009 年1月到2014 年12 月收治的44 例胃肠道间质瘤患者，采用免疫组化进行染色标记，结合临床病理特点对其进行回顾性分析。 1 资料与方法 1.1 一般资料：回顾性分析我院2009年1月～2014年12月收治的44例胃肠道间质瘤的患者临床资料。所有患者均经过临床确诊。男23例，女21例，年龄33～75岁，平均55.2岁。患者原发肿瘤的部位为：胃30例，小肠10例，结肠3例，直肠1例。临床以腹痛、腹胀、腹部肿块为主要症状。 1.2 方法（1）收集患者的临床资料，复习HE 切片，并对患者进行随访。（2）采用免疫组化EnVinsion 法对44 例GIST 进行CD117、CD34、DOG-1、Vim、Ki-67、desmin、S-100