eIF4E表达在大肠肿瘤发生发展中的作用及其潜在的诊断价值.docVIP

精品论文 参考文献 eIF4E表达在大肠肿瘤发生发展中的作用及其潜在的诊断价值 黄金凤1 雍伟伟2 姚运红2 吴孟宴2 康海仙2 尹金宝2 敖秋月2 别延红2 胡新荣2(通讯作者) (1佛山市顺德区中医院病理科 广东顺德 528333) (2广东医学院肿瘤研究所、病理教研室 广东东莞 523808) 【摘要】目的：探讨eIF4E蛋白表达在大肠癌发生发展中的作用和诊断意义。方法：用免疫组化方法检测145例大肠石蜡标本的eIF4E表达。病例包括大肠炎25例、腺瘤40例、腺癌40例、转移性腺癌40例。结果：依大肠炎、腺瘤、腺癌、转移性腺癌的次序,eIF4E阳性表达率分别为12.0%、80.0%、85.0%、100%，其中大肠炎组分别与其他三组比较，Plt;0.01；腺瘤组与腺癌组比较，Pgt;0.05；腺瘤组和腺癌组分别与转移性腺癌组比较，Plt;0.05。依I、II、III、IV临床分期次序，eIF4E阳性表达率分别为62.5%、82.8%、96.6%、100%，Plt;0.01。eIF4E阳性表达与性别、年龄、发生部位、浸润深度、分化程度等无关。eIF4E阳性表达从大肠炎中诊断腺瘤的敏感性为85.0%，特异性为88.0%；从腺瘤中诊断腺癌的敏感性为92.5%，特异性为17.7%。结论：eIF4E在大肠粘膜演变成腺瘤和腺癌、从未转移性腺癌演变成转移性腺癌、从早期癌到晚期癌中表达显著升高，提示eIF4E可以促进大肠肿瘤的发生发展，具有潜在的预后和诊断价值。 【关键词】大肠肿瘤 eIF4E 转移 【中图分类号】R735.3+4 【文献标识码】A 【文章编号】2095-1752（2013）18-0393-03 The role and diagnosis value of the expression of eIF4E in the occurrence and development of colorectal tumors Huang Jinfeng1 Yon Weiwei2 Yao Yunhong2 Wu Mengyan2 Kang Haixian2 Yin Jinbao2 Ao Qiuyue2 Bie Yanhong2 Hu Xinrong2（Correspondent author） (1 Department of pathology, Shunde traditional Chinese medical hospital, Shunde, 528333； 2 Department of pathology，cancer institute, Guangdong Medical College, Dongguan 523808) 【Abstract】Objective: To explore the role of eIF4E in occurrence and development of colorectal tumors and the diagnosis value of the eIF4E expression. Methods: Immunohistochemistry was used to detect the eIF4E expression in 145 cases of colorectal tissues. The cases included 25 colitis, 40 adenomas, 40 adenocarcinomas and 40 metastatic adeno-carcinomas. Results: In the order of colitis, adenoma, adenocarcinoma and metastatic adenocarcinoma, the eIF4E expression rates were 12.0%, 80.0%, 85.0% and 100%，respectively, Plt;0.01 between colitis and the three tumor groups, Pgt;0.05 between adenoma and adenocarcinoma, and Plt;0.05 between adenoma and adenocarcinoma and metastatic adenocarcinoma. In the order of the clinical phase I, II, III and IV of the malignancies, the expressio