心肺复苏患者血清S100β蛋白的动态变化及其临床意义.pdfVIP

生 鲞 l2期 Chinese Journ~of Pracfic~Medicine June．2008，Vo1．35．No．12 · 7· 心肺复苏患者血清 s10013蛋白的动态变化及其临床意义 于兰芳 王水云 余振东 金安民 李红艳 王娘娣 郑绮雯 (北京大学深圳医院，深圳 518036) 【摘要】 目的 探讨心肺复苏患者血清SIO0~蛋白的动态变化及其临床意义。方法 对67例心跳、呼吸骤停的患者进 行标准心肺复苏，动态检测67例心搏骤停复苏患者和33例对照者血清SIO0~蛋白水平。结果 SIO0~蛋白在心肺复 苏不同时间30、45 min、1、2、8、24、48、72 h有脑损伤和无脑损伤者比较，P0．05，差异有统计学意义。自主循环恢复后 2 h伴有脑损害者SIO0~蛋白为(4．2±0、7) g／L，没有恢复自主循环者S10013蛋白为(3．5±0．5) g／L，而没有脑损伤 者为(0．8±0．5) g／L，差异有统计学意义。结论 心搏骤停自主循环恢复后血清S10013蛋白水平明显升高，这是早期 判断心搏骤停复苏后有否脑损伤的敏感指标。 【关键词】 心搏骤停；脑损伤；SlO0~蛋白 Changes and clinical significance of serum SlO0[3 in cardiopulmonary resuscitated patients YU Lan一 ng，WANG Shuiyttrt，YU Zhendong，JINAnmin LI Hongyan， ，vG Niangdi，ZHENG Qiwen．Shenzhen Hospi— tal of Be ng University，Shenzhen 518036，Guangdong 【Abstract】 Objective To investigate the changes and clinical significance of serum S1 00 B in cardiop— ulmonary resuscitated patients．Methods Serum S1 00 p concentrations were detected by ELISA in 67 patients with cardiac and respiratory sudden arrest treating with standard cardi0pulm0nary resuscitation and 3 3 normal control group，and dynamic detecting the level of blood S 1 00 B of cardiopulmonary resusci— tated patients．Results Blood samples in 67 patients were taken for the determination of S1 00 B．Maxi— mum S1 00[3 levels within 2 hours after cardiac arrest were significantly higher in patients with documented brain damage[surviors and nonsurviors，(4．2±0．7) g／L]than in patients without brain damage [(0．8±0．5)I．Lg／L]．Significant differences between these two groups were observed from 30 minutes until 72 hours after cardiac arrest．Conclusion Astroglial protein S1 00 p is an early and sensitive marker of hypoxic brain after cardiac arrest in humans． 【Key words】 Heart arrest cardiopulmonary resuscitation；Brain damage；SlO0[3 protein 在美国每年约有35