胱抑素C、同型半胱氨酸和超敏CRP与早期糖尿病肾病的关系研究.docVIP

精品论文 参考文献 胱抑素C、同型半胱氨酸和超敏CRP与早期糖尿病肾病的关系研究 （三峡大学第一临床医学院宜昌市中心人民医院，湖北 宜昌 443003） 中图分类号 R587.1 文献标志码 A 文章编号 1008-0408（2015）2-0081-03 摘 要 目的：探讨早期糖尿病肾病患者测定胱抑素C（CysC）、同型半胱氨酸（Hcy）及超敏CRP（hs-CRP）的临床意义，为早期诊治糖尿病肾病提供科学依据。方法：随机抽取本院收治的108例糖尿病患者，经诊断，其中58例单纯糖尿病患者，50例早期糖尿病肾病患者，分别设为单纯糖尿病组、早期糖尿病肾病组，同时选取60例健康人员作为健康对照组，对其展开CysC、Hcy及hs-CRP检测，而后对比分析检测结果。结果：与健康对照组比较，单纯糖尿病组与早期糖尿病肾病组血清CysC、Hcy及hs-CRP水平均升高，差异有统计学意义（P＜0.05），与单纯糖尿病组比较，早期糖尿病肾病组血清CysC、Hcy及hs-CRP水平均升高，差异有统计学意义（P＜0.05）；与健康对照组比较，单纯糖尿病组CysC、Hcy及hs-CRP阳性率均无统计学意义（P gt; 0.05），与健康对照组及单纯糖尿病组比较，早期糖尿病肾病组血清CysC、Hcy及hs-CRP阳性率均增高，差异有统计学意义（P＜0.05）；早期糖尿病肾病组组间比较发现，CysC和hs-CRP组阳性率显著高于Hcy组（P＜0.05）。结论：CysC、Hcy及hs-CRP都能够反映糖尿病患者早期的肾脏损伤情况，其中，CysC及hs-CRP作为早期糖尿病肾病患者检测指标较好，Hcy次之。 关键词 糖尿病肾病；胱抑素C；同型半胱氨酸；超敏CRP The relationship between Cystatin C, homocysteine, and high-sensitivity CRP and early stage diabetic nephropathy Zhang Qingyong Luo Chunhua Fujing*（First College of Clinical Medical Science, China Three Gorges University, Department of Clinical Laboratory of Yichang Central Peoplersquo;s Hospital, Yichang, Hubei Province, 443003） Abstract Objective: To investigate the expression of cystatin C (CysC), homocysteine #8203;#8203;(Hcy) and high-sensitivity CRP (hs-CRP) in patients with the early stage diabetic nephropathy and its clinical significance, provide a scientific basis for early diagnosis and treatment of diabetic nephropathy. Methods: We randomly selected 108 patients with diabetes, 58 cases of simple diabetic patients and 50 patients with early stage diabetic nephropathy, which were set simple diabetic group and early stage diabetic nephropathy group, at the same time selected 60 healthy persons as control group, CysC, Hcy and hs-CRP were examined, then comparative analysis of test results. Results: Compared with healthy control group, the levels of CysC, Hcy and hs-CRP were increased in simple diabetic group and early stage diabetic nephropathy group(P lt;0.05), compared with the simple diabetic group, the leve