胱抑素C检测在高胆红素血症新生儿肾功能监测中的临床意义.docVIP

精品论文 参考文献 胱抑素C检测在高胆红素血症新生儿肾功能监测中的临床意义 贾国昌（舞钢巿人民医院检验科 462500） 【摘要】目的 探讨胱抑素C检测在高胆红素血症新生儿肾功能监测中的临床意义。方法　收集2012年1月至2012年12月我院妇产科高胆红素血症新生儿标本64例（总胆红素水平ge;260umol/L）作为观察组；20例对照组标本为同期出生的无高胆红素血症新生儿（总胆红素水平le;150umol/L）。所有标本采集均为股静脉血3ml，对肾功进行：尿素（UREA）、肌酐（CR）、胱抑素C（CYS-C）检测，高胆红素血症患儿经治疗黄疸消退后，复查胆红素和胱抑素C。并对检测结果进行归类处理。结果　64例高胆红素血症新生儿标本与20例对照组标本肾功能检测。结果　尿素、肌酐结果二者无显著差异（P＞0.05）;胱抑素C结果二者差异显著（P＜0.05）。高胆红素血症新生儿经治疗黄疸消退后，复查总胆红素和胱抑素C结果，胆红素和胱抑素水平与治疗前相比差异显著（P＜0.05）。结论　对高胆红素血症新生儿进行胱抑素C检测可早期、有效监测高胆红素血症对新生儿造成的肾损伤情况，有助于临床及时采取有效的干预治疗手段。 【关键词】 高胆红素血症 胱抑素C 肾损伤 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2013）27-0102-02 Study cystation C in hyperbilirubinemia newborns for renal function of clinical significance JIA GUO-CHANG Wu Gang city Peoplersquo;s hospital clinical laboratory of He Nan province 【Abstract】 Objective Study cystation C in hyperbilirubinemia newborns for renal function of clinical significance. Methods 64 cases of hyperbilirubinemia newborns (TBILge;260umol/L) as observed group were collected from department of obstetrics and gynecology from January 2012 to December 2012;20 cases without hyperbilirubinemia newborns (TBILle;150umol/L) as the control group at the same time. All specimen collection for femoral venous blood 3ml,Renal function test: UREA and CR and CYS-C, Children with hyperbilirubinemia after treatment of jaundice subsided review of cystation C. And to classify the test results. Result 64 cases of hyperbilirubinemia and 20 cases of control group in renal function test results: UREA and CR results both had no significant difference (Pgt;0.05) and cystation C result had significant difference (Plt;0.05). Hyperbilirubinemia newborns after treatment of jaundice subsided, Review the result of TBIL and cystation C had no significant difference （Pgt;0.05）. Conclusion Cystation C with hyperbirubinemia newborns testing early and effective monitoring of hyperbilirubinemia levels in neonatal kidney damage case, help clinical tim