Ss CT引导下125I粒子植入联合全身化疗治疗晚期非小细胞肺癌的临床观察.docVIP

精品论文 参考文献 Ss CT引导下125I粒子植入联合全身化疗治疗晚期非小细胞肺癌的临床观察 林辉 苏香花 肖建宏 彭锦芸 (福建医科大学附属闽东医院呼吸科 福建福安 355000) 【摘要】目的 探讨观察CT引导下125I放射性粒子植入联合吉西他滨、顺铂(GP方案)化疗治疗晚期非小细胞肺癌(NSCLC)的临床疗效和安全性。方法　66例Ⅲb～Ⅳ期NSCLC患者分为(实验组)30例：采用CT引导下粒子植入联合全身化疗和(对照组)36例：化疗组，两组化疗方案均为吉西他滨联合顺铂，术后l、3、6个月分别进行随访做CT检查，观察各自有效率和毒副反应。结果 实验组和对照组的总体有效率分别为 80.00％和50.00％，两组间有显著的统计学差异(plt;0.05)，所有的不良反应及并发症可控，实验组有较高的血痰和胸痛、气胸发生率(plt;0.05)，两组在发热、骨髓抑制方面无差异((pgt;0.05))，所有患者末出现放射损伤症状、未发现粒子迁移。结论 放射性粒子125I植入联合化疗治疗晚期非小细胞肺癌有较好的近期临床疗效和可以控制的毒副不良反应，是晚期非小细胞肺癌安全、有效的治疗手段。 【关键词】非小细胞肺癌 放射性粒子125I 化疗 近距离放疗 【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2013）13-0118-03 Curative Effect of CT-guided 125I seeds implantation combined with chemotherapy for Advanced Non-small cell Lung Cancer Lin Hui Su Xiang-hua, Xiao Jian-hong, Peng Jin-yun Respiratory department of Min Dong hospital of Fu Jian Medical university, Fu An FuJian, China, 355000 【Abstract】Objective To explore the curative effect and safety of CT-guided radioactive 125I seeds implantation combination with GP regimen(GEM+DDP) chemotherapy for advanced non-small cell lung cancer (NSCLC). Methods The 66 cases NSCLC patients (Ⅲb～Ⅳstage)were randomly divided into two groups: CT-guided seeds implantation combined with chemotherapy group(experimental group, n=30) and pure chemotherapy group (control group, n=36), two groups were both accepted GP regimen(GEM+DDP) chemotherapy. And they were followed up by CT examination after l, 3 ,6 months. The efficacy and adverse effects of both groups were compared. Results In the CT-guided seeds implantation combined with chemotherapy group and the pure chemotherapy group, the response rate (CR plus PR) was 80.0% and 50.0%, respectively. There were significant differences in two groups (plt;0.05). All the adverse reactions and complications were controllable. The experimental group had higher bloody sputum, chest pain and pneumothorax incidence(plt;0.05), but, there were no significant differen