antitumor compounds from marine actinomycetes抗肿瘤化合物从海洋放线菌.pdfVIP

Mar. Drugs 2009, 7, 210-248; doi:10.3390/md7020210 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Antitumor Compounds from Marine Actinomycetes Carlos Olano, Carmen Méndez and José A. Salas * Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain; E-Mails: olanocarlos@uniovi.es (C.O.); cmendezf@uniovi.es (C.M.) * Author to whom correspondence should be addressed; E-Mail: jasalas@uniovi.es; Tel.: +34-985- 103652; Fax: +34-985-103652 Received: 25 May 2009; in revised form: 8 June 2009 / Accepted: 11 June 2009 / Published: 11 June 2009 Abstract: Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting