有哪些信誉好的足球投注网站analysis of mitochondrial 3d-deformation in cardiomyocytes during active contraction reveals passive structural anisotropy of orthogonal short axes在心肌细胞线粒体分析3 d-deformation主动收缩揭示被动结构的正交各向异性短轴.pdfVIP
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analysis of mitochondrial 3d-deformation in cardiomyocytes during active contraction reveals passive structural anisotropy of orthogonal short axes在心肌细胞线粒体分析3 d-deformation主动收缩揭示被动结构的正交各向异性短轴
Analysis of Mitochondrial 3D-Deformation in
Cardiomyocytes during Active Contraction Reveals
Passive Structural Anisotropy of Orthogonal Short Axes
1 1 1 2 1
Yael Yaniv , Magdalena Juhaszova , Su Wang , Kenneth W. Fishbein , Dmitry B. Zorov , Steven J.
Sollott1*
1 Laboratory of Cardiovascular Science, Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore,
Maryland, United States of America, 2 Laboratory of Clinical Investigation, Gerontology Research Center, Intramural Research Program, National Institute on Aging,
National Institutes of Health, Baltimore, Maryland, United States of America
Abstract
The cardiomyocyte cytoskeleton, composed of rigid and elastic elements, maintains the isolated cell in an elongated
cylindrical shape with an elliptical cross-section, even during contraction-relaxation cycles. Cardiomyocyte mitochondria are
micron-sized, fluid-filled passive spheres distributed throughout the cell in a crystal-like lattice, arranged in pairs sandwiched
between the sarcomere contractile machinery, both longitudinally and radially. Their shape represents the extant 3-
dimensional (3D) force-balance. We developed a novel method to examine mitochondrial 3D-deformation in response to
contraction and relaxation to understand how dynamic forces are balanced inside cardiomyocytes. The variation in
transmitted light intensity induced by the periodic lattice of myofilaments alternating with mitochondrial rows can be
analyzed by Fourier transformation along a given cardiomyocyte axis to measure mitochondrial deformation along that axis.
This technique enables pr
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