anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of cd44r1 expressed on cancer stem cells抗肿瘤效应对人类肿瘤异种移植完全人类单克隆抗体的变异8-epitope cd44r1表示癌症干细胞.pdfVIP

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anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of cd44r1 expressed on cancer stem cells抗肿瘤效应对人类肿瘤异种移植完全人类单克隆抗体的变异8-epitope cd44r1表示癌症干细胞.pdf

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anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of cd44r1 expressed on cancer stem cells抗肿瘤效应对人类肿瘤异种移植完全人类单克隆抗体的变异8-epitope cd44r1表示癌症干细胞

Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8- Epitope of CD44R1 Expressed on Cancer Stem Cells 1 1 1 1 1 1 1 Kazue Masuko , Shogo Okazaki , Mayumi Satoh , Goh Tanaka , Tatsuya Ikeda , Ryota Torii , Eri Ueda , 1 1 1 1 1 Takashi Nakano , Masaaki Danbayashi , Tomoyo Tsuruoka , Yoshiya Ohno , Hideki Yagi , Noritsugu 2 3 3 3 4 4 Yabe , Hideaki Yoshida , Tomoyuki Tahara , Shiro Kataoka , Taichi Oshino , Takayuki Shindo , Shin- 4 5 5 6{ 7 ichiro Niwa , Takatsugu Ishimoto , Hideo Baba , Yoshiyuki Hashimoto , Hideyuki Saya , Takashi Masuko1,8* 1 Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, Higashiosaka-shi, Osaka, Japan, 2 Kohjin Bio Co., Ltd., Saitama, Japan, 3 Kyowa Hakko Kirin Co., Ltd., Chiyoda-ku, Tokyo, Japan, 4 Link Genomics, Inc., Chuo-ku, Tokyo, Japan, 5 Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Honjo, Kumamoto, Japan, 6 Tohoku University, Sendai, Japan, 7 Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan, 8 Pharmaceutical Research and Technology Institute, Kinki University, Higashiosaka-shi, Osaka, Japan Abstract Background: CD44 is a major cellular receptor for hyaluronic acids. The stem struc