antiretroviral therapy optimisation without genotype resistance testing a perspective on treatment history based models抗逆转录病毒疗法优化没有基因型电阻测试角度治疗历史基础模型.pdfVIP
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antiretroviral therapy optimisation without genotype resistance testing a perspective on treatment history based models抗逆转录病毒疗法优化没有基因型电阻测试角度治疗历史基础模型
Antiretroviral Therapy Optimisation without Genotype
Resistance Testing: A Perspective on Treatment History
Based Models
1,2,3 4 ´ 5 6
Mattia C. F. Prosperi *, Michal Rosen-Zvi , Andre Altmann , Maurizio Zazzi , Simona Di
1 7 ¨ 7 8 9 10
Giambenedetto , Rolf Kaiser , Eugen Schulter , Daniel Struck , Peter Sloot , David A. van de Vijver ,
11 ¨ 12
Anne-Mieke Vandamme , Anders Sonnerborg for the EuResist and Virolab study groups
1 Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy, 2 Informa CRO, Rome, Italy, 3 College of Medicine, Pathology, Immunology and Laboratory
Medicine, EPI, University of Florida, Gainesville, Florida, United States of America, 4 IBM Haifa Research Lab, Haifa, Israel, 5 Max Planck Institute for Informatics,
¨ ´
Saarbrucken, Germany, 6 University of Siena, Siena, Italy, 7 University of Cologne, Cologne, Germany, 8 Centre de Recherche Public-Sante, Luxembourg, Luxembourg,
9 Universiteit van Amsterdam, Amsterdam, The Netherlands, 10 Department of Virology, Erasmus MC, University Medical Centre Rotterdam, Utrecht, The Netherlands,
11 Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium, 12 Karolinska Institute, Stockholm, Sweden
Abstract
Background: Although genotypic resistance testing (GRT) is recommended to guide combination antiretroviral therapy
(cART), funding and/or facilities to perform
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