antitumor peptides from marine organisms从海洋生物抗肿瘤多肽.pdfVIP

Mar. Drugs 2011, 9, 1840-1859; doi:10.3390/md9101840 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Antitumor Peptides from Marine Organisms Lan-Hong Zheng 1, Yue-Jun Wang 1, Jun Sheng 1, Fang Wang 1, Yuan Zheng 1, Xiu-Kun Lin 2,3,* and Mi Sun 1,* 1 Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; E-Mails: zhenglanhong@126.com (L.-H.Z.); wangyj@ (Y.-J.W.); shengjun01@ (J.S.); wendywf2002@ (F.W.); zhengyuan@ (Y.Z.) 2 Department of Pharmacology, Capital Medical University, Beijing 100069, China 3 Institute of Oceanology, Chinese Academy of Science, Qingdao 266071, China * Authors to whom correspondence should be addressed; E-Mails: linxiukun@ (X.-K.L.); sunmi0532@ (M.S.); Tel.: +86-532(X.-K.L.); +86-532(M.S.); Fax: +86-532(X.-K.L.); +86-532(M.S.). Received: 12 July 2011; in revised form: 8 September 2011 / Accepted: 22 September 2011 / Published: 10 October 2011 Abstract: The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affec