有哪些信誉好的足球投注网站anti-transforming growth factor ？ antibody treatment rescues bone loss and prevents breast cancer metastasis to boneanti-transforming生长因子抗体治疗救助骨质流失,预防乳腺癌骨转移.pdfVIP
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anti-transforming growth factor ？ antibody treatment rescues bone loss and prevents breast cancer metastasis to boneanti-transforming生长因子抗体治疗救助骨质流失,预防乳腺癌骨转移
Anti-Transforming Growth Factor ß Antibody Treatment
Rescues Bone Loss and Prevents Breast Cancer
Metastasis to Bone
1,5 3 6 2 2 2
Swati Biswas *, Jeffry S. Nyman , JoAnn Alvarez , Anwesa Chakrabarti , Austin Ayres , Julie Sterling ,
2 1 2 2,3,4 7 6
James Edwards , Tapasi Rana , Rachelle Johnson , Daniel S. Perrien , Scott Lonning , Yu Shyr ,
Lynn M. Matrisian5, Gregory R. Mundy2,5
1 Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 2 Center for Bone Biology, Vanderbilt
University School of Medicine, Nashville, Tennessee, United States of America, 3 Department of Orthopedics, Vanderbilt University School of Medicine, Nashville,
Tennessee, United States of America, 4 Vanderbilt University Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of
America, 5 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 6 Department of Biostatistics,
Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 7 Genzyme Corporation, Framingham, Massachusetts, United States of America
Abstract
Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFb. Because TGFb
favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFb antibody may
reduce tumor burden and rescue tumor-associated bone loss in metastatic breast can
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