anti-tnf-α activity of portulaca oleracea in vascular endothelial cellsanti-tnf-α在血管内皮细胞的活动.pdfVIP

Int. J. Mol. Sci. 2012, 13, 5628-5644; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Anti-TNF-αActivity of Portulaca oleracea in Vascular Endothelial Cells An Sook Lee 1,†, Jin Sook Kim 2,†, Yun Jung Lee 1,3, Dae Gill Kang 1,3,* and Ho Sub Lee1,3,* 1 College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea; E-Mails: mama0099@ (A.S.L.); shrons@wku.ac.kr (Y.J.L.) 2 Korea Institute of Oriental Medicine, Jeonmin-dong, Yusung-gu, Daejeon, 305-811, Republic of Korea; E-Mail: jskim@kiom.re.kr 3 Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: dgkang@wku.ac.kr (D.G.K.); host@wku.ac.kr (H.S.L.); Tel.: +82-63-850-6933 (D.G.K.); +82-63-850-6841 (H.S.L.); +82-63-850-7260 (D.G.K.); Fax: +82-63-850-7260 (H.S.L.). Received: 20 February 2012; in revised form: 20 April 2012 / Accepted: 2 May 2012 / Published: 10 May 2012 Abstract: Vascular inflammation plays a key role in the pathogenesis and progression of atherosclerosis, a main complication of diabetes. The present study investigated whether an aqueous extract of Portulaca oleracea (AP) prevents the TNF-α-induced vascular inflammatory process in the human umbilical