多亲本杂交衍生的多个相关群体QTL作图的通用方法.pdfVIP

中国水稻科学(Chinese J Rice Sci)，2008，22(4)：427～431 httpt{{ ．ricesci．cn 427 多亲本杂交衍生的多个相关群体QTL作图的通用方法 敖 雁 胡治球 汤在祥 王学枫 徐辰武 (扬州大学江苏省作物遗传生理重点实验室，江苏 扬州 225009； 通讯联系人，E—mail：qtls@yzu．edu．cn) A General Method for QTL Mapping in Multiple Related Populations Derived from Multiple Parents Ao Yan，Hu Zhi—qiu，TANG Zai—xiang，WANG Xue—feng，XU Chen—WU (Key Laboratory of Crop GeneticsPhysiology of Jiangsu Province，Yangzhou University，Yangzhou 225009，China； Corresponding author，E-mail：qtls@yzu．edu．cn) Abstract：It’S well—known that incorporating some existing populations derived from multiple parents may improve QTL mapping and QTL-based breeding programs．However，no general maximum likelihood method has been available for this strategy．Based on the QTL mapping in multiple related populations derived from two parents，an maximum likelihood estima— tion method that can incorporate several populations derived from three or more parents and can be used tO handle different mating designs was proposed．Taking the circle design as an example，simulation studies were performed tO study the impact of QTL heritability and sample size upon the proposed method．The results showed that under the same heritability，higher QTL detection power and more exact and accurate estimation of parameters could be obtained when three F2 populations were analyzed jointly than when only any two F2 populations were analyzed simultaneously；and higher heritability，especially with larger sample sizes would increase the ability of QTL detection and improve the estimation of parameters．Potential advantages of the method are as follows：firstly，the existing results of QTL mapping in single population can be compared and integrated with each other using this proposed method，SO the ability of QTL detection and precision of QTL mapping can be improved． Secondly，owing tO multiple allele