ARGR表达与前列腺癌生物学行为的关系.pdfVIP

Journal of Medical Forum Vo1．29 No．5 March 2008 ·13· AR GR表达与前列腺癌生物学行为的关系 闫天中，张祥生，李启忠 河南省人民医院泌尿外科 郑州市 450003 摘要 目的 探讨不同病理前列腺组织q-雄激素受体(AR)、糖皮质激素受体(GR)的表达变化及与前列 腺癌生物学行为的关系。方法 选取l5例人正常前列腺(NP)组织、25例良性前列腺增生(BPH)组织、57例前 列腺癌(PCa)组织，对PCa进行Gleason分级，并根据临床雄激素阻断治疗效果分为雄激素依赖组(ADPC，n= 39)和雄激素非依赖组(AIPC，n=18)，免疫组化检测手术标本AR、GR、PSA的表达并分析其与Gleason分级的 关系。结果 从NP、BPH到ADPC组织，AR表达呈逐渐升高趋势，而GR表达呈逐渐降低趋势，当进展到AIPC 时，AR表达明显降低，GR表达明显升高(P0．05)。随着Gleason分级的增高，AR表达逐渐降低．GR表达逐 渐升高(P0．05)。结论 GR抑制了前列腺癌细胞的分化，长期雄激素阻断治疗导致AR表达降低，GR表达 升高，AR／GR信号途径失衡是前列腺癌雄激素非依赖进展的重要原因。 关键词 前列腺癌；雄激素受体；糖皮质激素受体 中图分类号：R737．25 文献标识码：A 文章编号：1672-3422(2008)05-0013-03 Relation of AR and GR Expressions to Biological Behavior of Prostate Cancer YAN Tianzhong，ZHANG Xiangsheng，L1 Qizhong Department of Urology，Henan Provincial Peoples Hospital，Zhengzhou 450003，China ABSTRACT Objective To explore the variation of androgen receptor(AR)and glucocorti- coid receptor(GR)in prostate tissues and the relation to biological behavior of prostate cancer (PCa)．Methods Total 57 cases of PCa were graded according to Gleason score and were divided in- to androgen dependent PCa(ADPC，n=39)and androgen independent PCa(AIPC，n=18)accord- ing to clinical effect of androgen—ablation．The expression of AR and GR protein were detected by im- munohistochemistry in tissue specimens obtained from PCa patients by operation and the relation be- tween the expressions of AR and GR and Gleason grade was analyzed，with 1 5 cases of normal prostate (NP)and 25 cases of benign prostatic hyperplasia(BPH)tissues as contro1．Results The expression of AR decreased gradually and GR increased gradually from(NP)，BPH to ADPC tissues，But the ex- pression of AR decreased in AIPC significantly and GR expressio