复方青秦液对尿酸性肾病大鼠肾功能的影响.docVIP

复方青秦液对尿酸性肾病大鼠肾功能的影响 　　摘要：目的 观察复方青秦液对尿酸性肾病大鼠肾功能的影响，探讨其肾脏保护作用。方法 将SD大鼠随机分为正常组、模型组、阳性药组及中药大、中、小剂量组，用腺嘌呤灌胃伴饲酵母造模。正常组及模型组每日灌胃蒸馏水，阳性药组每日灌胃别嘌呤9.33 mg/kg，中药大、中、小剂量组每日灌胃复方青秦液3.77、1.89、0.09 g/kg，连续6周。观察各组大鼠一般情况，电镜、光镜观察肾脏病理变化，分别检测治疗前后尿蛋白浓度、血尿酸、血尿素氮、血肌酐、肾重指数。结果 造模前后各组大鼠进食、饮水及体质量无明显变化。复方青秦液可明显降低尿酸性肾病大鼠的尿蛋白浓度，降低血尿酸水平，降低血肌酐、尿素氮，减少肾重指数（P0.05），中药大剂量组大鼠肾小管上皮细胞萎缩及肾间质纤维化不明显。结论 复方青秦液对尿酸性肾病大鼠肾功能损伤具有保护作用。 　　关键词：复方青秦液；尿酸性肾病；肾功能；大鼠 　　DOI：10.3969/j.issn.1005-5304.2013.09.011 　　中图分类号：R285.5 文献标识码：A 文章编号：1005-5304（2013）09-0031-03 　　Effect of Compoud Qingqin Liquids on Renal Function of Uric Acid Nephropathy Rats SHANG Xue-zheng， MA Wei-guo， BAI Yu， FANG Tie-sheng， ZHANG Chun-yan， LIU Hui， LU Yan， GU Wen， XU Yu-mei， TANG Ling， MENG Feng-xian （Dongfang Hospital Affiliated to Beijing University of Chinese Medicine， Beijing 100078， China） 　　Abstract：Objective To observe the effect of Compoud Qingqin Liquids on renal function of rat model of uric acid nephropathy， and to discuss its protection of renal function. Methods The rat model was induced by gavaging adenine and feeding yeast. SD rats were randomly divided into control group， model group， positive group， and high-， medium-， low- dose groups of Chinese medicine. Blank control group and model group were daily gavaged with distilled water， positive control group was daily gavaged with allopurinol by 9.33 mg/kg， and high-， medium-， low-dose group of Chinese medicine was daily gavaged with Compound Qinggin Liguids by 3.77， 1.89， 0.09 g/（kg?d） respectively for 6 weeks. General condition of rats were observed， renal pathological changes were observed with light and electron microscope. Urine protein concentration， blood uric acid， blood urea nitrogen， creatinine and kidney weight index were respectively tested before and after treatment. Results There were no significant differences in eating， drinking and body weight between before and after modeling. Compoud Qingqin Liquids can obviously decrease the concentration of urine protein， bloo