丁苯酞对急性缺血性脑卒中患者血清C—反应蛋白的影响及临床疗效观察.docVIP

丁苯酞对急性缺血性脑卒中患者血清C—反应蛋白的影响及临床疗效观察 　　摘要] 目的 探讨丁苯酞对急性缺血性脑卒中患者血清C-反应蛋白的影响及其临床疗效。 方法 将146例AIS患者随机分为观察组及对照组，观察组在常规治疗的基础上加用丁苯酞胶囊，而对照组加用纤溶酶，治疗2周后观察其临床疗效及血清C-反应蛋白的变化。结果 观察组有效率明显高于对照组；治疗2周后，两组患者的CRP水平及NIHSS 评分较治疗前均明显降低（P0.05），观察组CRP水平及NIHSS 评分降低更为明显，差异具有统计学意义（P0.05）。 结论 应用丁苯酞可以显著降低AIS患者血清CRP浓度，显著改善其预后。 　　[关键词] 急性缺血性脑卒中；丁苯酞；C-反应蛋白 　　[中图分类号] R743.32 [文献标识码] B [文章编号] 1673-9701（2014）02-0024-02 　　The influence of dl-3n-butyphthalide on serum CRP level and the clinical curative effect in patients with acute ischemic stroke 　　CHEN Wei YI Jia 　　Department of Neurology， Peoples Hospital of Songzi in Hubei Province， Songzi 434200， China 　　[Abstract] Objective To explore the influence of dl-3n-butyphthalide on serum C-reactive protein（CRP） level and the clinical curative effect in patients with acute ischemic stroke. Methods A total of 146 patients with AIS were randomly divided into observation group and control group， the observation group received dl-3n-butyphthalide on the basis of conventional treatment，but the control group received fibrinolytic enzyme. Observed the clinical efficacy and the expression of C-reactive protein after the treatment for 2 weeks. Results The effect for the observation group was significantly higher than that of the control group（P 0.05）. After the treatment for 2 weeks，the expression of C-reactive protein and NIHSS scores of the two groups were significantly lower than that with no treatment（P0.05）， but the two indicators of the observation group were more significantly decreased than that of the control group （P 0.05）. Conclusion The dl-3n-butyphthalide could significantly decrease the level of CRP in patients with AIS， and it could significantly improve the prognosis of patients with AIS. 　　[Key words] Acute ischemic stroke； Dl-3n-butyphthalide； C-reactive protein 　　急性缺血性脑卒中（ acute ischemic stroke，AIS）是一种常见的脑血管疾病，有较高的致死率，且逐年上升[1]。C-反应蛋白（CRP）常常被用于评判AIS的严重程度和预后[2]。丁苯酞作为一种新型具有抗脑缺血再灌注损伤和神经保护作用的药物也在临床上广泛应用，能显著改善AIS患者的预后。本研究的目的在于探讨丁苯酞对AIS患者血清CRP