依那西普联合非甾体抗炎药治疗强直性脊柱炎的疗效评估.docVIP

精品论文 参考文献 依那西普联合非甾体抗炎药治疗强直性脊柱炎的疗效评估 田岚 （绵阳市中心医院免疫科 四川 绵阳 621000） 【摘要】 目的：研究依那西普联合非甾体抗炎药治疗强直性脊柱炎的疗效。方法：将2011年5月～2014年7月期间在我院就诊的强直性脊柱炎患者随机分为两组，实验组患者接受非甾体类药物联合依那西普治疗，对照组患者接受非甾体类药物联合抗风湿药物治疗，比较两组患者的临床情况及实验室指标。结果：实验组患者的腰部晨僵时间短于对照组，BASDAI、BASFI评分以及ESR、CRP水平均低于对照组。结论：依那西普联合非甾体抗炎药有助于缩短晨僵时间、减轻病情严重程度，是治疗强直性脊柱炎的理想方法。 【关键词】 强直性脊柱炎；依那西普；非甾体类药物；C反应蛋白 【中图分类号】R97 【文献标识码】A 【文章编号】2095-1752（2015）32-0030-02 Evaluation on the efficacy of etanercept combined with non-steroidal anti-inflammatory drug in treatingankylosing spondylitis Tian Lan. Department of Rheumatology, Mianyang Central Hospital, Sichuan Province,Mianyang 621000,China 【Abstract】 Objective To study the efficacy of etanercept combined with non-steroidal anti-inflammatory drug in treatingankylosing spondylitis. Methods Ankylosing spondylitis patients in our hospital duringMay 2011~July 2014 were randomly divided into two groups, the experimental group received non-steroidal drug combination etanercept treatment, the control group received non-steroidal combined with anti-rheumatic drug therapy. Then clinical condition and laboratory parameters of two groups were compared. Results Waist morning stiffness tduration of experimental group were shorter than the control group, BASDAI, BASFI score and ESR, CRP levels were lower than the control group. Conclusion Etanercept combined with non-steroidal anti-inflammatory drug is helpful toshorten morning stiffnessduration, reduce the severity of ankylosing spondylitis; ti is an ideal method for the treatment of ankylosing spondylitis. 【Key words】Ankylosing spondylitis; Etanercept; nonsteroidal drugs; C-reactive protein; 强直性脊柱炎（ankylosing spondylitis，AS）是一种主要累及中轴关节的慢性进行性炎症性疾病，随着病情的进展会逐步累及骶髂关节以及周围关节，严重时会造成患者躯体功能丧失。AS患者最突出的临床症状包括腰背部、颈部、髋部疼痛，严重者会出现脊柱畸形和强直，对日常生活造成极为不利的影响。目前，强直性脊柱炎尚缺乏根治的方法，临床治疗的主要思路是控制病情进展、缓解临床症状并提高日常生活能力。非甾体类药物联合抗风湿药物是临床治疗AS的常用方法，能够有效改善外周关节的相关症状，但是对中轴关节相关症状的改善作用并不理想。依那西普是近年来发