有哪些信誉好的足球投注网站a putative p-type atpase required for virulence and resistance to haem toxicity in listeria monocytogenes一个假定的p型atp酶毒性和耐药性所需血红素在单核细胞增多性李斯特氏菌的毒性.pdfVIP
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A Putative P-Type ATPase Required for Virulence and
Resistance to Haem Toxicity in Listeria monocytogenes
1. 3. 1,4 3 1
Heather P. McLaughlin , Qiaobin Xiao , Rosemarie B. Rea , Hualiang Pi , Pat G. Casey , Trevor
1 5,6 4 1 7 1
Darby , Alain Charbit , Roy D. Sleator , Susan A. Joyce , Richard E. Cowart , Colin Hill *, Phillip E.
Klebba3¤, Cormac G. M. Gahan1,2
1 Alimentary Pharmabiotic Centre, Department of Microbiology, University College Cork, Cork, Ireland, 2 School of Pharmacy, University College Cork, Cork, Ireland,
3 Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America, 4 Department of Biological Sciences, Cork Institute of
´ ´ ´ ´ ´
Technology, Cork, Ireland, 5 Universite Paris Descartes, Faculte de Medecine Necker-Enfants Malades, Paris, France, 6 INSERM, U1002, Unite de Pathogenie des Infections
´
Systemiques, Paris, France, 7 Division of Biological Science, Department of Natural and Applied Sciences, University of Dubuque, Dubuque, Iowa, United States of America
Abstract
Regulation of iron homeostasis in many pathogens is principally mediated by the ferric uptake regulator, Fur. Since
acquisition of iron from the host is essential for the intracellular pathogen Listeria monocytogenes, we predicted the
existence of Fur-regulated systems that support infection. We examined the contribution of nine Fur-regulated loci to the
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