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a novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease一种新型细菌与淋巴腺炎患者慢性肉芽肿性疾病
A Novel Bacterium Associated
with Lymphadenitis in a Patient with Chronic
Granulomatous Disease
1 1 2 2 2 1
David E. Greenberg , Li Ding , Adrian M. Zelazny , Frida Stock , Alexandra Wong , Victoria L. Anderson ,
3 4 5 3 6 2
Georgina Miller , David E. Kleiner , Allan R. Tenorio , Lauren Brinster , David W. Dorward , Patrick R. Murray ,
1*
Steven M. Holland
1 Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America,
2 Microbiology Service, Department of Laboratory Medicine, W. G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America,
3 Diagnostic and Research Services Branch, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Laboratory of Pathology, National Cancer Institute,
National Institutes of Health, Bethesda, Maryland, United States of America, 5 Section of Infectious Diseases, Department of Medicine, Rush Medical College, Chicago, Illinois,
United States of America, 6 Microscopy Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton,
Montana, United States of America
Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing
defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening
infections. We identified a novel gram-negative rod in excised lymph nodes from a patient with CGD. Gram-negative
rods grew on charcoal-yeast extract, but conventional tests could not id
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