a putative plant aminophospholipid flippase, the arabidopsis p4 atpase ala1, localizes to the plasma membrane following association with a β-subunit一种假定的植物aminophospholipid flippase,拟南芥p4腺苷三磷酸酶ala1,本地化后的质膜协会β-subunit.pdfVIP

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a putative plant aminophospholipid flippase, the arabidopsis p4 atpase ala1, localizes to the plasma membrane following association with a β-subunit一种假定的植物aminophospholipid flippase,拟南芥p4腺苷三磷酸酶ala1,本地化后的质膜协会β-subunit.pdf

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a putative plant aminophospholipid flippase, the arabidopsis p4 atpase ala1, localizes to the plasma membrane following association with a β-subunit一种假定的植物aminophospholipid flippase,拟南芥p4腺苷三磷酸酶ala1,本地化后的质膜协会β-subunit

A Putative Plant Aminophospholipid Flippase, the Arabidopsis P4 ATPase ALA1, Localizes to the Plasma Membrane following Association with a b-Subunit ´ ´ Rosa L. Lopez-Marques*, Lisbeth R. Poulsen, Michael G. Palmgren Department of Plant Biology and Biotechnology, Centre for Membrane Pumps in Cells and Disease (PUMPKIN), University of Copenhagen, Danish National Research Foundation, Frederiksberg, Denmark Abstract Plasma membranes in eukaryotic cells display asymmetric lipid distributions with aminophospholipids concentrated in the inner leaflet and sphingolipids in the outer leaflet. This unequal distribution of lipids between leaflets is, amongst several proposed functions, hypothesized to be a prerequisite for endocytosis. P4 ATPases, belonging to the P-type ATPase superfamily of pumps, are involved in establishing lipid asymmetry across plasma membranes, but P4 ATPases have not been identified in plant plasma membranes. Here we report that the plant P4 ATPase ALA1, which previously has been connected with cold tolerance of Arabidopsis thaliana, is targeted to the plasma membrane and does so following association in the endoplasmic reticulum with an ALIS protein b-subunit. ´ ´ Citation: Lopez-Marques RL, Poulsen LR, Palmgren MG (2012) A Putative Plant Aminophospholipid Flippase, the Arabidopsis P4 ATPase ALA1, Localizes to the Plasma Membrane following Association with a b-Subunit. PLoS ONE 7(4): e33042. doi:10.1371/journal.pone.0033042 Editor: Vladimir N. Uversky, University of South Florida College of Medicine, United States of America Received December 20, 2011; Accepted February 9, 2012; Published April 13, 2012 ´ ´ Copyright: 2012 Lopez-Marques et al. This is an open-access article distributed under the ter