有哪些信誉好的足球投注网站- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a novel behavioral assay for measuring cold sensation in mice一种新颖的行为在老鼠身上试验测量冷的感觉
A Novel Behavioral Assay for Measuring Cold Sensation
in Mice
1,2,3 1 1,2
Daniel S. Brenner , Judith P. Golden , Robert W. Gereau, IV *
1 Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
2 Neuroscience Program, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 Medical Scientist Training Program, Washington
University School of Medicine, St. Louis, Missouri, United States of America
Abstract
Behavioral models of cold responses are important tools for exploring the molecular mechanisms of cold sensation. To
complement the currently cold behavioral assays and allow further studies of these mechanisms, we have developed a new
technique to measure the cold response threshold, the cold plantar assay. In this assay, animals are acclimated on a glass
plate and a cold stimulus is applied to the hindpaw through the glass using a pellet of compressed dry ice. The latency to
withdrawal from the cooled glass is used as a measure of the cold response threshold of the rodents, and the dry ice pellet
provides a ramping cold stimulus on the glass that allows the correlation of withdrawal latency values to rough estimates of
the cold response threshold temperature. The assay is highly sensitive to manipulations including morphine-induced
analgesia, Complete Freund’s Adjuvant-induced inflammatory allodynia, and Spinal Nerve Ligation-induced neuropathic
allodynia.
Citation: Brenner DS, Golden JP, Gereau RW IV (2012) A Novel Behavioral Assay for Measuring Cold Sensation in Mice. PLoS ONE 7(6): e39765. doi:10.1371/
journal.pone.0039765
Editor: Man
您可能关注的文档
- a mechanochemical approach to porous silicon nanoparticles fabrication多孔硅纳米颗粒的机械化学的方法制造.pdf
- a mechanical model of cell segregation driven by differential adhesion细胞分离的机械模型由微分附着力.pdf
- a mechanism regulating the onset of sox2 expression in the embryonic neural plate发病的机制调节sox2表达在胚胎神经板.pdf
- a meta-analysis of array-cgh studies implicates antiviral immunity pathways in the development of hepatocellular carcinoma全息阵列研究的荟萃分析其中牵扯到的抗病毒免疫通路在肝细胞癌的发展.pdf
- a membrane fusion protein αsnap is a novel regulator of epithelial apical junctions膜融合蛋白αsnap是一种新型调节器的上皮细胞顶端连接.pdf
- a mathematical model for interpretable clinical decision support with applications in gynecology一种数学模型解释的在妇科临床决策支持应用程序.pdf
- a meta-analysis of seaweed impacts on seagrasses generalities and knowledge gaps一个荟萃分析的海藻对海草概论和知识差距的影响.pdf
- a meta-analysis of probiotic efficacy for gastrointestinal diseases益生菌功效的荟萃分析胃肠道疾病.pdf
- a meta-analysis of predation risk effects on pollinator behaviour捕食风险的荟萃分析影响传粉者行为.pdf
- a mechanistic model of pcr for accurate quantification of quantitative pcr datapcr的机械模型准确定量pcr的量化数据.pdf
- a novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity一种新颖的基于抗体的慢性藻毒素暴露生物标志物和sub-acute神经毒性.pdf
- a novel biochemical route for fuels and chemicals production from cellulosic biomass一种新的生化途径从纤维素生物质生产燃料和化学品.pdf
- a novel apoptosis correlated molecule expression and characterization of protein latcripin-1 from lentinula edodes c91–3一种新的细胞凋亡相关分子表达和描述的蛋白质latcripin-1地区香菇c91-3.pdf
- a novel approach for automated analysis of cell attachment and spreading based on backscattered electron imaging by scanning electron microscopy自动化分析的新方法细胞附着和传播根据扫描电镜的背散射电子成像.pdf
- a novel computational strategy to identify a-to-i rna editing sites by rna-seq data de novo detection in human spinal cord tissue新颖的计算策略识别a-to-i rna编辑网站通过rna-seq数据新创检测人类脊髓组织.pdf
- a nonparametric test reveals selection for rapid flowering in the arabidopsis genome非参数测试表明选择快速开花在拟南芥基因组中.pdf
- a novel cogging torque simulation method for permanent-magnet synchronous machines一种新型齿轮扭矩永磁同步机的模拟方法.pdf
- a novel co-polymer based on hydroxypropyl α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector一种新颖的基于羟丙基丙烯α-cyclodextrin共轭低分子量表面进行体外基因传递载体.pdf
- a novel endogenous inhibitor of the secreted streptococcal nad-glycohydrolase一种新型链球菌nad-glycohydrolase分泌的内源性抑制剂.pdf
- a novel cyclodextrin glycosyltransferase from alkaliphilic amphibacillus sp. npst-10 purification and properties一种新型环糊精糖基转移酶从alkaliphilic amphibacillus sp。npst-10净化和属性.pdf
文档评论（0）