有哪些信誉好的足球投注网站a putative alzheimers disease risk allele in pck1 influences brain atrophy in multiple sclerosis假定的阿尔茨海默氏症的风险等位基因在多发性硬化症pck1影响脑萎缩.pdfVIP
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a putative alzheimers disease risk allele in pck1 influences brain atrophy in multiple sclerosis假定的阿尔茨海默氏症的风险等位基因在多发性硬化症pck1影响脑萎缩
A Putative Alzheimer’s Disease Risk Allele in PCK1
Influences Brain Atrophy in Multiple Sclerosis
1,2,5 1,2 3 4,7 1,2,5
Zongqi Xia , Lori B. Chibnik , Bonnie I. Glanz , Maria Liguori , Joshua M. Shulman , Dong
1,2 5 5 6 5 4
Tran , Samia J. Khoury , Tanuja Chitnis , Todd Holyoak , Howard L. Weiner , Charles R. G. Guttmann ,
Philip L. De Jager1,2,5*
1 Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America,
2 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, 3 Department of Neurology, Brigham and Women’s
Hospital, Boston, Massachusetts, United States of America, 4 Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Boston,
Massachusetts, United States of America, 5 Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, United
States of America, 6 Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, 7 Institute of
Neurological Sciences, National Research Council, Mangone, Italy
Abstract
Background: Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a
candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer’s Disease
(AD) influence brain volume and cognition in MS patients.
Methods/Principal Findings: M
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