p57~（kip2）、LIMK1与宫颈癌淋巴结转移的关系.pdfVIP

· 1588· 杜 岚，等 p57“、LIMK1与宫颈癌淋巴结转移的关系 p57 、LIMK1与宫颈癌淋巴结转移的关系 杜 岚，史 欣，李东红，王 秀，苏 青 Therelationshipofp57 ‘andLIMK1withlymphatiCmetastasisofcervicalcancer DuLan，ShiXin，LiDonghong，WangXiu，SuQing DepartmentofGynaecologyandObstetrics，TheForthHospital，ShaanxiXian710004，China． A【bstract】 0bjecfive：Toevaluatetheexpressionlevelofp57 andLIMK1incervicalcarcinoma，toexplorethe roleofp57 andLIMK1inthegenesisandprogressionofcervicalcarcinoma．M ethods：Weevaluatedp57 ‘and LIMK1byimmunohistochemistryin37cervicalcarcinomatissuesandcomparedto37adjacentnon——canceroustis-· sues．Themutualrelationshipsforclinicopathologicfactorandp57 aswellasLIMK1wereanalysed．Results：The expressionofp57 incervicalcarcinoma(29．7％1wassignificantlylowerthanthatinadjacentnon—canceroustis— sues(86．5％)(P0．05)．Theabsenceofp57“p2wasassociatedwithadvancedcervicalcarcinoma(Ⅲ +IVstage) andlymphaticmetastasis(P0．05)．TheexpressionofLIMK1(40．5％)decreasedincervicalcarcinomacomparedto adjacentnon—canceroustissues(75．7％)(P0．05)．TheabsenceofLIMK1wasassociatedwithlymphaticmetasta— sisofcervicalcarcinoma(P0．05)．Moreover，thepositivecorrelationbetweenp57’andLIMK1wasobservedin cervicalcarcinomatissues(P0．05)．Conclusion：Theabnormalexpressionofp57 andLIMK1mightparticipate intheocculTenceandprogressionofcervicalcarcinoma，andcoordinatelyregulatelymphaticmetastasisofcervical Can cer． 【Keywords】p57“；mRNA；protein；cervicalcarcinoma ModernOncology2013，21(07)：1588—1591 【摘要】 目的：检测细胞周期抑制因子p57“和细胞骨架蛋白LIMK1在宫颈癌中的表达水平，探讨两者在宫 颈癌发生发展中的作用。方法：用免疫组织化学方法检测37例宫颈癌组织和37例宫颈癌旁组织中p57“和 LIMK1的表达水平 ；分析 p57 和LIMK1与宫颈癌临床病理因素的关系及两者间的关系。结果：p57“在宫 颈癌组织中的阳性率29．7％，显著低于癌旁宫颈组织(86．5％)(P0．05)，p57“皿的缺失表达与进展期宫颈 癌(Ⅲ期+Ⅳ期)和淋巴结转移有关 (P0．05)。LIMK1在宫颈癌组织中的阳性率40．5％，显著低于癌旁宫 颈组织(75．7％)(P0．05)，LIMK1的低表达