leep刀联合重组牛碱性成纤维细胞生长因子凝胶治疗宫颈糜烂的疗效观察.docVIP

LEEP刀联合重组牛碱性成纤维细胞生长因子凝胶治疗宫颈糜烂的疗效观察 　　摘 要 目的：探讨LEEP刀联合重组牛碱性成纤维细胞生长因子凝胶治疗宫颈糜烂的疗效。方法：收集2015年6月至2016年6月收治的宫颈糜烂患者58例，随机分为试验组和对照组各29例。对照组接受LEEP刀治疗，试验组接受LEEP刀和重组牛碱性成纤维细胞生长因子凝胶治疗，观察两组临床疗效、不同时间创面愈合情况、治疗前后糜烂面积评分和阴道清洁评分。结果：试验组治疗总有效率为100.00%（29/29），对照组为86.21%（25/29）组间差异有统计学意义（P 　　关键词 宫颈糜烂；LEEP刀；重组牛碱性成纤维细胞生长因子；疗效 　　中图分类号：R711.74 文献标志码：A 文章编号：1006-1533（2017）04-0024-02 　　Observation of efficacy of LEEP knife combined with recombinant bovine basic fibroblast growth factor gel in the treatment of cervical erosion 　　ZHANG Julian1， LIAO Jiefei2， HU Shufang2（1.Obstetrics and Gynecology Department of Central Hospital of Xinyu Iron Steel Group Co. Ltd， Xinyu 338000， Jiangxi Province， China； 　　2.Chengnan Community Health Service Center of Xinyu District， Xinyu 338000， Jiangxi Province， China） 　　ABSTRACT Objective： To investigate the therapeutic effect of LEEP knife combined with recombinant bovine basic fibroblast growth factor gel in the treatment of cervical erosion. Methods： Fifty-eight cases of cervical erosion treated from June 2015 to June 2016 were collected and randomly divided into an experimental group and a control group with 29 cases each. The control group received LEEP knife treatment and the experimental group received LEEP knife combined with recombinant bovine basic fibroblast growth factor gel treatment. The clinical effect， different time of wound healing， the erosion area score and vaginal cleanliness score of the two groups were observed before and after treatment. Results： The total effective rates of the experimental group and the control group were 100.00%（29/29） and 86.21%（25/29） and the difference was statistically significant（P 　　KEY WORDS cervical erosion； LEEP knife； recombinant bovine basic fibroblast growth factor； therapeutic effect 　　宫颈糜烂是妇科常见慢性炎性疾病，多发于中年女性。临床研究表明，宫颈糜烂是宫颈癌的高危因素[1]。LEEP刀属于高频电波刀，是治疗宫颈糜烂的微创术式，效果明确[2]。重组牛碱性成纤维细胞生长因子凝胶能促进宫颈上皮细胞生成，加速LEEP刀治疗的创面愈合，提高治疗效果[3]。本文报道LEEP刀联合重组牛碱性成纤维细胞生长因子凝胶治疗宫颈糜烂的临床优势。 　　1 资料与方法 　　1.1 一般资料 　　收集2015年6月至2016年