co2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣疗效观察.docVIP

CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣疗效观察 　　[摘要] 目的 探讨CO2激光联合咪喹莫特乳膏和干扰素治疗尖锐湿疣临床疗效。 方法 随机选取2010年7月―2015年1月该院皮肤性病科门诊诊治的191例尖锐湿疣患者，随机分成3组，A组65例，B组63例，C组63例。A组：CO2激光联合咪喹莫特乳膏和重组人干扰素α-2b治疗。B组：CO2激光联合重组人干扰素α-2b治疗。C组：单纯用CO2激光治疗。开始2个月每周随访1次，以后每3周随访1次，随访6个月。结果 A、B、C 3组治愈率分别为93.85%、80.95%、58.73%，复发率分别为6.15%、19.05%、41.27%。使用咪喹莫特乳膏辅助 CO2激光治疗尖锐湿疣的疗效明显优于干扰素α-2b辅助CO2激光与单纯用CO2激光治疗；同时，使用咪喹莫特乳膏辅助CO2激光治疗尖锐湿疣的?头⒙拭飨孕∮谄溆嗔街种瘟品绞剑?两种差异有统计学意义（P 　　[关键词] 咪喹莫特；干扰素；尖锐湿疣 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）05（b）-0039-03 　　[Abstract] Objective To observe the clinical curative effect of CO2 laser and Imiquimod cream and interferon in treatment of condyloma acuminate. Methods Random selection 191 cases of patients with condyloma acuminate treated in our hospital from July 2010 to January 2015 were randomly divided into three groups， the group A with 65 cases adopted the CO2 laser and Imiquimod cream and recombinant human interferonα-2b treatment， the group B with 63 cases adopted the CO2 laser and recombinant human interferonα-2b treatment， and the group C with 63 cases only adopted the CO2 laser treatment， in the first two months， all patients were followed up once， and followed up once every three weeks， 6 cases in total. Results The cure rate and recurrence rate in the group A， B and C were respectively 93.85%， 80.95%， 58.73% and 6.15%， 19.05%， 41.27%， and the curative effect of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously better than that of interferon α-2b and CO2 laser and simple CO2 laser， at the same time， the recurrence rate of Imiquimod cream and CO2 laser in treatment of condyloma acuminate was obviously fewer than that of the other treatment methods， and the differences between groups were statistically significant（P 　　1 资料与方法 　　1.1 一般资料 　　随机选取了该院2010年7月―2015年1月期间收治的尖锐湿疣（CA）患者191例，均为有尖锐湿疣（CA）典型的临床表现和不洁性交史或配偶感染史患者，使用5%醋酸白试验呈阳性，所以，所有患者均符合尖锐湿疣（CA）的诊断标准。其中，男患者102例，年龄19～60岁，平均年龄为（29.5±3.8） 岁；女患者89例，年龄18～59岁，平均年龄为（28.9±4.1） 岁；所有患者病程为12～17个月，平均病程为（3.2±1.5）个月；