双联抗血小板药物治疗脑梗死对血小板功能和近期预后的影响.docVIP

精品论文 参考文献 双联抗血小板药物治疗脑梗死对血小板功能和近期预后的影响 （宁夏灵武市人民医院 内二科 宁夏 灵武 750400） 【摘 要】目的：探究阿双联抗血小板药物治疗脑梗死患者对血小板功能和近期预后的影响。方法：选择急性脑梗死患者140例，分为实验组和对照组,每组70例。对照组患者给予阿司匹林口服治疗，实验组给予氯吡格雷联合阿司匹林药物口服治疗,对两组预后进行比较。结果：实验组患者血小板聚集率和血小板-白细胞聚集体明显低于对照组、复发率及预后不良率显著低于对照组,差异显著，具有统计学意义（P＜0.05）。结论：双联抗血小板药物治疗脑梗死患者能够显著抑制血小板活化功能，并明显降低复发率、改善患者预后。 【关键词】抗血小板治疗；脑梗死；血小板功能；预后 【中图分类号】R743.3 【文献标识码】B 【文章编号】1004-6194（2015）02-0439-02 Effect of Dual Antiplatelet Therapy on Platelet Function and Recent Prognosis in Patients with Cerebral Infarction 【Abstract】Objective: To explore the effect of the treatment of cerebral infarction patients with cerebral infarction on platelet function and short-term prognosis of patients with cerebral infarction. Methods: 140 patients with acute cerebral infarction were divided into experimental group and control group, 70 cases in each group. The control group was given aspirin, and the experimental group was treated with clopidogrel and aspirin, and the prognosis of the two groups was compared. Results: patients in the experimental group platelet aggregation rate and platelet leukocyte aggregates was significantly lower than that of the control group, recurrence rate and bad prognosis rate was significantly lower than that of the control group, significant difference has statistical significance (P lt; 0.05). Conclusion: dual anti platelet drugs can significantly inhibit the platelet activation in patients with cerebral infarction, and significantly reduce the recurrence rate, improve the prognosis of patients. 【Key words】Antiplatelet therapy; Platelet function; Cerebral Infarction; Prognosis 阿司匹林和氯吡格雷进行双联抗血小板治疗时抗血小板效果较好，但对于脑梗死患者应用的治疗效果仍然存在争议。本文选择我院2014年1月～2014年12月收治的急???脑梗死患者140例研究双联抗血小板药物治疗脑梗死患者对血小板功能和近期预后的影响。现报告如下。 1 资料与方法 1.1一般资料：病例来源于我院于2014年6月～2014年12月收治的脑梗死患者140例。按随机数字表法将纳入病例分为实验组和对照组，对应随机数字为偶数者为实验组，奇数者为对照组，每组70例。实验组：男42例，女28例；年龄50～75岁，平均（62.8plusmn;3.5）岁；发病时间为5-72 h，平均时间为（49.3plusmn;4.1）h；单侧基底节梗死46例，双侧基底节梗死24例。对照组：男39例，女31例；年龄50～75