NP和GP方案治疗晚期非小细胞肺癌临床对比研究的Meta分析.docVIP

精品论文 参考文献 NP和GP方案治疗晚期非小细胞肺癌临床对比研究的Meta分析 胡尔西旦木 崔智文 顾艳侠（伊犁州新华医院肿瘤.消化科 新疆伊宁 835000） 【摘要】 目的:采用Meta分析比较NP和GP方案治疗晚期非小细胞肺癌在有效率和骨髓抑制方面的优缺点。方法:检索有关NP和GP方案治疗晚期非小细胞肺癌的临床对比研究,分别对入选的研究进行文献评价,进行Meta分析。结果:从1994年～2005年共有12个研究入选,实验组413例。对照组共401例。分析结果显示:有效率RR值为1.05,95%可信区间为0.90～1.23,总体效应检验Z=0.63,Pgt;0.05,无统计学意义;白细胞下降RR值为1.43,95%可信区间为1.26～1.61,总体效应检验Z=5.58,Plt;0.05,有统计学意义;血小板下降RR值为0.83,95%可信区间为0.72～0.96,总体效应检验Z=2.44,Plt;0.05,有统计学意义。结论:NP和GP方案均为治疗晚期非小细胞肺癌的有效方案。GP方案对白细胞的影响小而对血小板的影响大。敏感性分析和发表性偏倚的识别结果表明,本次Meta分析的结果稳定,可靠。 【关键词】 NP方案 GP方案 晚期非小细胞肺癌 Meta分析 【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2013）12-0089-02 Meta analysis on curative effects ofNP and GP schem es in the therapy ofadvanced non-small cell lung cancer LI Jian-ying,LIUAn,CHEN Bao-qing Xian ZhongxinHospitalRespiratoryDepartment,Xian710004,China. 【Abstract】 Objective:To investigate the effective rate and arrest of bone marrow (decrease of leucocytes, plate-let) ofneoadjuvant chemotherapy schemesNP and GP in the therapy of advanced non- small cell lung cancer by Meta analysis.M ethods:After generally collection the clinical literatures published in domestic and overseas from1994 to 2005 that reported on the effective rate and arrestofbonemarrow (decrease of leukocyte, platelet) ofneoad-juvant chemotherapy schemesNP andGP in the therapy ofadvanced non- small cell lung cancer, Meta analysiswas performed are processed byReviewManager4. 2 program, selecting fixed or random modelbased on the heterogeneity test.Results:12 literatureswere selected forMeta analysis based on our including and excluding standers. There was no difference between the effective rates ofNP and GP schemes, but decrease of leukocyte was greater in NP schemes, decrease of plateletwas greater in GP schemes.Conclusion:NP and GP schemes are effective in therapy ofnon- small cell lung cancer.Decrease of leukocyte and platelet are two adverse effects. Decrease of leukocyte is greater in NP schemes, decreas