GP方案治疗晚期乳腺癌的临床疗效观察.docVIP

精品论文 参考文献 GP方案治疗晚期乳腺癌的临床疗效观察 徐珍1 陆超2 刘永1 徐建忠1（1苏州大学附属常州肿瘤医院肿瘤内科八病区 江苏常州 213001）（2苏州大学附属常州肿瘤医院药剂科临床药学室 江苏常州 213001） 【摘要】目的 观察GP方案治疗晚期乳腺癌的临床疗效与不良反应。方法 吉西他滨1250mg/m2，d1、8*Q21d；顺铂25mg/m2，d1-3天*Q21d。化疗过程中观察不良反应，两周期后评价疗效。结果 36例晚期乳腺癌患者共完成化疗156周期，其中CR2例，PR18例，SDl0例，PD6例，有效率55.6％(20/36)，控制率83.3%（30/36）。主要的不良反应为骨髓抑制及消化道反应，乏力、脱发、发热及皮疹也比较常见，而口腔溃疡等皮肤黏膜反应的发生率相对较少，未发现有明显的神经毒性及肾功能损害。结论 GP方案作为二线药物治疗晚期乳腺癌疗效较好，且不良反应相对较小，患者可以耐受，值得临床进一步推广。 【关键词】 晚期乳腺癌 吉西他滨 顺铂 疗效观察 【中图分类号】R论著【文献标识码】A【文章编号】2095-1752（2012）29-0105-02 Clinical curative effect Observation on Treatment of Late Stage of Breast Carcinoma with GP Regimen Xu Zhen[1]、Lu Chao[2]、Liu Yong[1]、Xu Jianzhong[1] 1.Changzhou Tumor Hospital Affiliated to SuZhou University ,the eighth of Oncology endemic area Jiangsu changzhou 213001 2.Changzhou Tumor Hospital Affiliated to SuZhou University,Clinical Pharmacy department of Pharmacy,Jiangsu changzhou 213001 【Abstract】 Objective To observe the clinical efficacy and adverse reaction of GP regimen for the treatment of last stage breast carcinoma. Methods Gemcitabine 1250mg/m2 was infused intravenously at d1 and d8 * Q21d. Cisplatin 25mg/m2 was infused intravenously at d1-3 * Q21d. The adverse reaction was observed during the chemotherapy, and the efficacy was evaluated after 2 courses of chemotherapy. Results 156 courses of the chemotherapy were completed by 36 cases of such patient. In these cases, complete response(CR)、partial response(PR)、stable disease(SD)、progressive disease(PD) were observed in 2、18、10、6 cases respectively. The overall response rete was 55.6％(20/36), and the total disease control rate was 83.3%（30/36）. The major adverse reaction was gastrointestinal response and myelosuppression, weak、alopecia、fever and rash were common, but skin mucous membrane reaction such as canker sore was happened rarely, obvious neurotoxicity and renal damage had not been happened yet. Conclusion GP Regimen as a second-line chemotherapy regim