white matter abnormalities correlating with memory and depression in heroin users under methadone maintenance treatment白质异常关联与记忆和抑郁症在吸食海洛因美沙酮维持治疗.pdfVIP

white matter abnormalities correlating with memory and depression in heroin users under methadone maintenance treatment白质异常关联与记忆和抑郁症在吸食海洛因美沙酮维持治疗.pdf

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white matter abnormalities correlating with memory and depression in heroin users under methadone maintenance treatment白质异常关联与记忆和抑郁症在吸食海洛因美沙酮维持治疗

White Matter Abnormalities Correlating with Memory and Depression in Heroin Users under Methadone Maintenance Treatment 1,2 3 4 2 1,2 Wei-Che Lin , Kun-Hsien Chou , Chien-Chih Chen , Chu-Chung Huang , Hsiu-Ling Chen , Cheng- 5 6 4 1 2,3 Hsien Lu , Shau-Hsuan Li , Ya-Ling Wang , Yu-Fan Cheng , Ching-Po Lin * 1 Department of Diagnostic Radiology, Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 2 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 3 Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, 4 Department of Psychiatry, Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 5 Department of Neurology, Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 6 Department of Internal Medicine, Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan Abstract Methadone maintenance treatment (MMT) has elevated rates of co-morbid memory deficit and depression that are associated with higher relapse rates for substance abuse. White matter (WM) disruption in MMT patients have been reported but their impact on these co-morbidities is unknown. This study aimed to investigate changes in WM integrity of MMT subjects using diffusion tensor image (DTI), and their relationship with history of heroin and methadone use in treated opiate-dependent individuals. The ass

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