有哪些信誉好的足球投注网站whole blood dna aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease a pilot study全血dna异常甲基化在胰腺腺癌显示与疾病的初步研究.pdfVIP
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whole blood dna aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease a pilot study全血dna异常甲基化在胰腺腺癌显示与疾病的初步研究
Whole Blood DNA Aberrant Methylation in Pancreatic Adenocarcinoma Shows Association with the Course of the Disease: A Pilot Study 1 1 2 2 3 Albertas Dauksa , Antanas Gulbinas *, Giedrius Barauskas , Juozas Pundzius , Johannes Oldenburg , Osman El-Maarri3* 1 Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania, 2 Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania, 3 Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Germany Abstract Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. Non-invasive early detection would greatly enhance therapy and survival rates. Toward this aim, we investigated in a pilot study the power of methylation changes in whole blood as predictive markers for the detection of pancreatic tumors. We investigated methylation levels at selected CpG sites in the CpG rich regions at the promoter regions of p16, RARbeta, TNFRSF10C, APC, ACIN1, DAPK1, 3OST2, BCL2 and CD44 in the blood of 30 pancreatic tumor patients and in the blood of 49 matching controls. In addition, we studied LINE-1 and Alu repeats using degenerate amplification approach as a surrogate marker for genome-wide methylation. The site-specific methylation measurements at selected CpG sites were done by the SIRPH method. Our results show that in the patient’s blood, tumor suppressor genes were slightly but significantly higher methylated at several CpG sites, while repeats were slightly less methylated compared to control blood. This was found to be significantly associated with higher risk for pancreatic ductal adenocarcinoma. Additionally, h
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