white matter correlates of neuropsychological dysfunction in systemic lupus erythematosus白质的神经心理功能障碍相关系统性红斑狼疮.pdfVIP

White Matter Correlates of Neuropsychological Dysfunction in Systemic Lupus Erythematosus 1,2 2 2 3 4 Rex E. Jung *, Robert S. Chavez , Ranee A. Flores , Clifford Qualls , Wilmer L. Sibbitt Jr. , Carlos A. Roldan4 1 Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico, United States of America, 2 Mind Research Network, University of New Mexico, Albuquerque, New Mexico, United States of America, 3 Department of Mathematics, and University of New Mexico, Albuquerque, New Mexico, United States of America, 4 Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America Abstract Patients diagnosed with Systemic Lupus Erythematosus have similar levels of neuropsychological dysfunction (i.e., 20–50%) as those with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). We hypothesized a gradient between cognition and white matter integrity, such that strongest brain-behavior relationships would emerge in NPSLE, intermediate in non-NPSLE, and minimal in controls. We studied thirty-one patients (16 non-NPSLE; 15 NPSLE), ranging in age from 18 to 59 years old (100% female), and eighteen age and gender matched healthy controls. DTI examinations were performed on a 1.5T scanner. A broad neuropsychological battery was administered, tapping attention, memory, processing speed, and executive functioning. The Total z-score consisted of the combined sum of all neuropsychological measures. In control subjects, we found no significant FA-Total z-score correlations. NPSLE, non-NPSLE, and control subjects differed significantly in terms of Total z-score (NPSLE = 22.25+/ 21.77, non-NPSLE = 21.22+/ 21.03, Controls = 20.10+/ 2.57; F = 13