when the genome plays dice circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses当基因组玩骰子的规避主轴装配检查点和随机染色体隔离在多极癌症细胞有丝分裂.pdfVIP

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when the genome plays dice circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses当基因组玩骰子的规避主轴装配检查点和随机染色体隔离在多极癌症细胞有丝分裂.pdf

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when the genome plays dice circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses当基因组玩骰子的规避主轴装配检查点和随机染色体隔离在多极癌症细胞有丝分裂

When the Genome Plays Dice: Circumvention of the Spindle Assembly Checkpoint and Near-Random Chromosome Segregation in Multipolar Cancer Cell Mitoses 1,2 ˚ 3 4 4 1 David Gisselsson *, Ulf Hakanson , Patrick Stoller , Dominik Marti , Yuesheng Jin , Anders H. 5 ´ 1 6 1 Rosengren , Ylva Stewenius , Fredrik Kahl , Ioannis Panagopoulos 1 Department of Clinical Genetics, Lund University Hospital, Lund, Sweden, 2 Department of Pathology, Lund University Hospital, Lund, Sweden, 3 The Nanometer Structure Consortium, Division of Solid State Physics, Lund University, Lund, Sweden, 4 Institute of Applied Physics, University of Bern, Bern, Switzerland, 5 Department of ¨ Clinical Sciences Malmo, Lund University, Lund, Sweden, 6 Department of Mathematics, Lund University, Lund, Sweden Abstract Background: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution. However, this notion has been little validated experimentally. Principal Findings: Chromosome segregation and DNA content in daughter cells from multipolar mitoses were assessed by multiphoton cross sectioning and fluorescence in situ hybridization in cancer cells and non-neoplastic transformed cells. The DNA distribution resulting from multipolar cell division was found to be highly variable, with frequent nullisomies in the daughter cells. T