when tuberculosis comes back who develops recurrent tuberculosis in california当肺结核回来发展复发肺结核在加州.pdfVIP

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when tuberculosis comes back who develops recurrent tuberculosis in california当肺结核回来发展复发肺结核在加州.pdf

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when tuberculosis comes back who develops recurrent tuberculosis in california当肺结核回来发展复发肺结核在加州

When Tuberculosis Comes Back: Who Develops Recurrent Tuberculosis in California? 1 2 3 1 Lisa Pascopella *, Kathryn DeRiemer , James P. Watt , Jennifer M. Flood 1Tuberculosis Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, California, United States of America, 2 School of Medicine, University of California Davis, Davis, California, United States of America, 3 Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, California, United States of America Abstract Background: Recurrent tuberculosis suggests potentially modifiable gaps in tuberculosis treatment and control activities. The frequency of late recurrences following treatment completion has not been well-studied. We determined the frequency of, and risk factors associated with, tuberculosis that recurs at least one year after completion of anti-tuberculosis therapy in California. Methods: The study population included culture-positive, pulmonary tuberculosis patients reported to the California tuberculosis case registry from 1993 to 2007 who completed anti-tuberculosis therapy. A person with late recurrent tuberculosis was defined as an individual that appeared in the registry more than once, determined by match on name and date-of-birth, with at least one year between treatment completion of the first episode and treatment initiation of the second episode. Results: Among 23,517 tuberculosis patients, 148 (0.63%) had a late recurrence. Independent risk factors for recurrence included: infection with a pyrazinamide mono-resistant isolate (adjusted hazard ratio, 2.93; p = 0.