有哪些信誉好的足球投注网站antihypertensive effect of long-term oral administration of jellyfish (rhopilema esculentum) collagen peptides on renovascular hypertension长期口服抗高血压效应的水母(rhopilema esculentum)胶原蛋白肽在肾血管性高血压.pdfVIP
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antihypertensive effect of long-term oral administration of jellyfish (rhopilema esculentum) collagen peptides on renovascular hypertension长期口服抗高血压效应的水母(rhopilema esculentum)胶原蛋白肽在肾血管性高血压
Mar. Drugs 2012, 10, 417-426; doi:10.3390/m
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Communication
Antihypertensive Effect of Long-Term Oral Administration of
Jellyfish (Rhopilema esculentum) Collagen Peptides on
Renovascular Hypertension
Yongliang Zhuang *, Liping Sun, Yufeng Zhang and Gaoxiang Liu
Research Center of Food Engineering, College of Chemistry and Engineering, Kunming University of
Science and Technology, Kunming, Yunnan 650600, China; E-Mails: kmlpsun@ (L.S.);
zhangyufeng062@163.com (Y.Z.); lgx1110@126.com (G.L.)
* Author to whom correspondence should be addressed; E-Mail: kmylzhuang@;
Tel./Fax: +86-871-3801122.
Received: 25 December 2011; in revised form: 31 January 2012 / Accepted: 6 February 2012 /
Published: 15 February 2012
Abstract: Antihypertensive effect of long-term oral administration of jellyfish
(Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs)
was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were
significantly reduced with administration of JCP (p 0.05), compared with model control
group. However, the arterial blood pressure of normal rats showed no significant changes
during long-term oral treatment with high dose JCP (p 0.05). Furthermore, effect of JCP
on angiotensin II (Ang II) concentration of plasma had no significance (p 0.05), but JCP
significantly inhibited the Ang II concentration in RVHs’ kidney (p 0.05). The kidney
should be the target site of JCP.
Keywords: jellyfish; collagen
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