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anti-inflammatory activity of chitooligosaccharides in vivo抗炎活性低聚糖在体内
Mar. Drugs 2010, 8, 1763-1768; doi:10.3390/md8061763
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Communication
Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
João C. Fernandes 1,*, Humberto Spindola 2, Vanessa de Sousa 2, Alice Santos-Silva 3,4,
1 1 2
Manuela E. Pintado , Francisco Xavier Malcata and João E. Carvalho
1 CBQF/Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Dr. António
Bernardino de Almeida, P-4200-072 Porto, Portugal; E-Mails: mmpintado@esb.ucp.pt (M.E.P.);
fxmalcata@docente.ismai.pt (F.X.M.)
2 CPQBA/Divisão de Farmacologia e Toxicologia, Universidade Estadual de Campinas, Campinas,
São Paulo, Brazil; E-Mails: hmspindola@ (H.S.); vanahelena@ (V.d.S.);
carvalho_je@.br (J.E.C.)
3 Serviço de Bioquímica, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha,
P-4050-047 Porto, Portugal; E-Mail: assilva@ff.up.pt (A.S.-S.)
4 Instituto de Biologia Molecular e Celular (IBMC) da Universidade do Porto, Rua do Campo Alegre,
P-4169-007 Porto, Portugal
* Author to whom correspondence should be addressed; E-Mail: jfernandes@;
Tel.: +351-96-7892999; Fax: +351-22-5090351.
Received: 15 April 2010; in revised form: 14 May 2010 / Accepted: 26 May 2010 /
Published: 28 May 2010
Abstract: All the reports to date on the anti-inflammatory activity of chitooligosaccharides
(COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of
two COS mixtures is characterized in vivo (using b
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