有哪些信誉好的足球投注网站anti-idiotypic antibody specific to gad65 autoantibody prevents type 1 diabetes in the nod mouseanti-idiotypic抗体针对gad65自身抗体预防1型糖尿病nod小鼠.pdfVIP
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anti-idiotypic antibody specific to gad65 autoantibody prevents type 1 diabetes in the nod mouseanti-idiotypic抗体针对gad65自身抗体预防1型糖尿病nod小鼠
Anti-Idiotypic Antibody Specific to GAD65 Autoantibody
Prevents Type 1 Diabetes in the NOD Mouse
1 . 2. 3 1 4 5 6
Xin Wang * , Aixia Zhang , Yu Liu , Shi Chen , Zhenqing Feng , Wenbin Shang , Marlena Maziarz ,
6 6
Jared Radtke , Christiane S. Hampe *
1 Department of Endocrinology, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu, China, 2 School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China,
3 Department of Endocrinology, 2nd Hospital of Jilin University, Changchun, Jilin, China, 4 Key Laboratory of Antibody Technology of Ministry of Health, Nanjing Medical
University, Nanjing, Jiangsu, China, 5 Medical Research Center, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China,
6 University of Washington, Seattle, Washington, United States of America
Abstract
Overt autoantibodies to the smaller isoform of glutamate decarboxylase (GAD65Ab) are a characteristic in patients with
Type 1 diabetes (T1D). Anti-idiotypic antibodies (anti-Id) directed to GAD65Ab effectively prevent the binding of GAD65 to
GAD65Ab in healthy individuals. Levels of GAD65Ab-specific anti-Id are significantly lower in patients with T1D, leading to
overt GAD65Ab in these patients. To determine the possible protective role of GAD65Ab-specific anti-Id in T1D
pathogenesis, we developed the monoclonal anti-Id MAb 8E6G4 specifically targeting human monoclonal GAD65Ab b96.11.
MAb 8E6G4 was demonstrated as a specific anti-Id directed to the antigen binding site of b96.11. MAb 8E6G4 recognized
human antibodies in sera from healthy individuals, T2D patients, and T1D patients as established by ELIS
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