an essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in apoe-- mice一个重要角色在exercise-mediated饮食预防血脂异常、炎症和动脉粥样硬化的载脂蛋白eu2014u2014老鼠.pdfVIP
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an essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in apoe-- mice一个重要角色在exercise-mediated饮食预防血脂异常、炎症和动脉粥样硬化的载脂蛋白eu2014u2014老鼠
An Essential Role for Diet in Exercise-Mediated
Protection against Dyslipidemia, Inflammation and
Atherosclerosis in ApoE-/- Mice
1 1 1 1 1
Liliana Cesar , Samuel Vasallo Suarez , Jennipher Adi , Nikhil Adi , Roberto Vazquez-Padron , Hong
1 1 1 3 2 1
Yu , Qi Ma , Pascal J. Goldschmidt-Clermont , Arthur Agatston , Paul Kurlansky , Keith A. Webster *
1 Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of
America, 2 Florida Heart Research Institute, Miami Beach, Florida, United States of America, 3 Agatston Research Institute, Miami Beach, Florida, United States of America
Abstract
Background: Diet and exercise promote cardiovascular health but their relative contributions to atherosclerosis are not fully
known. The transition from a sedentary to active lifestyle requires increased caloric intake to achieve energy balance. Using
atherosclerosis-prone ApoE-null mice we sought to determine whether the benefits of exercise for arterial disease are
dependent on the food source of the additional calories.
Methods and Results: Mice were fed a high-fat diet (HF) for 4.5 months to initiate atherosclerosis after which time half were
continued on HF while the other half were switched to a high protein/fish oil diet (HP). Half of each group underwent
voluntary running. Food intake, running distance, body weight, lipids, inflammation markers, and atherosclerotic plaque
were quantified. Two-way ANOVA tests were used to assess differences and interactions between groups. Exercised m
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