an estimation of radiobiological parameters for head-and-neck cancer cells and the clinical implications头颈部肿瘤细胞的放射生物参数的估计及临床意义.pdfVIP

Cancers 2012, 4, 566-580; doi:10.3390/cancers4020566 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications X. Sharon Qi 1, Qiuhui Yang 2, Steve P. Lee 1, X. Allen Li 2 and Dian Wang 2,* 1 Department of Radiation Oncology, University of California Los Angeles, 200 ULCA Medical Plaza, Los Angeles, CA 90024, USA 2 Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA * Author to whom correspondence should be addressed; E-Mail: dwang@; Tel.: +1-414-805-4496; Fax: +1-414-805-4369. Received: 12 April 2012; in revised form: 29 May 2012 / Accepted: 6 June 2012 / Published: 15 June 2012 Abstract: In vitro survival measurements using two human head-and-neck cancer (HNC) cell lines were performed. The specially designed split-dose surviving fraction was obtained and fitted to the linear-quadratic formalism. The repair halftime (Tr), the potential doubling time (T ), α/β and radiosensitivity α, were estimated. Other radiobiological d models: EUD, BED, TCP, etc., were used to examine the potential treatment effectiveness of different IMRT techniques. Our data indicated the repair halftime of ~17 min based on two HNC cell lines. The combined α/β, α and T are α/β = 8.1 ± 4.1 Gy, α = 0.22 ± 0.08 Gy−1, d Td = 4.0 ± 1.8 day,