有哪些信誉好的足球投注网站an essential role for the proximal but not the distal cytoplasmic tail of glycoprotein m in murid herpesvirus 4 infection近的重要作用但不是糖蛋白m的远端胞质尾鼠科动物感染疱疹病毒4.pdfVIP
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an essential role for the proximal but not the distal cytoplasmic tail of glycoprotein m in murid herpesvirus 4 infection近的重要作用但不是糖蛋白m的远端胞质尾鼠科动物感染疱疹病毒4
An Essential Role for the Proximal but Not the Distal
Cytoplasmic Tail of Glycoprotein M in Murid Herpesvirus
4 Infection
Janet S. May., Christopher M. Smith., Michael B. Gill., Philip G. Stevenson*
Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Abstract
Murid herpesvirus-4 (MuHV-4) provides a tractable model with which to define common, conserved features of gamma-
herpesvirus biology. The multi-membrane spanning glycoprotein M (gM) is one of only 4 glycoproteins that are essential for
MuHV-4 lytic replication. gM binds to gN and is thought to function mainly secondary envelopment and virion egress, for
which several predicted trafficking motifs in its C-terminal cytoplasmic tail could be important. We tested the contribution
of the gM cytoplasmic tail to MuHV-4 lytic replication by making recombinant viruses with varying C-terminal deletions.
Removing an acidic cluster and a distal YXXW motif altered the capsid distribution somewhat in infected cells but had little
effect on virus replication, either in vitro or in vivo. In contrast, removing a proximal YXXW motif as well completely
prevented productive replication. gM was still expressed, but unlike its longer forms showed only limited colocalization with
co-transfected gN, and in the context of whole virus appeared to support gN expression less well. We conclude that some
elements of the gM cytoplasmic tail are dispensible for MuHV-4 replication, but the tail as a whole is not.
Citation: May JS, Smith CM, Gill MB, Stevenson PG (2008) An Essential Role for the Proximal but Not the Distal Cytoplasmic Tail of Glycoprotein M in Murid
Herpesvirus 4 Infection. PLoS ONE 3(5): e2131. doi:10.1371/journal.pone.0002131
Editor: Peter Sommer, Institut Pasteur Korea, Republic of Korea
Received February 22, 2008; Accepted March 31, 2008; Published May 7, 2008
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