有哪些信誉好的足球投注网站aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in ratsaliskiren防止腹膜透析液的毒性作用在大鼠慢性透析.pdfVIP
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aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in ratsaliskiren防止腹膜透析液的毒性作用在大鼠慢性透析
Aliskiren Prevents the Toxic Effects of Peritoneal Dialysis
Fluids during Chronic Dialysis in Rats
´ ´ 3 ´ ´ 4 ´ 4 ´ ´ 3 ´ 3
Juan Perez-Martınez , Francisco C. Perez-Martınez , Blanca Carrion , Jesus Masia , Agustın Ortega ,
5 6 ´ ˜ 1,2
Esther Simarro , Syong H. Nam-Cha , Valentın Cena *
´
1 Unidad Asociada Neurodeath, Departamento de Ciencias Medicas, CSIC-Universidad de Castilla-La Mancha, Albacete, Spain, 2 CIBERNED, Instituto de Salud Carlos III,
Madrid, Spain, 3 Department of Nephrology, Complejo Hospitalario Universitario, Albacete, Spain, 4 Department of Research and Development, NanoDrugs, S.L., Parque
´ ´
Cientıfico y Tecnologico, Albacete, Spain, 5 Department of Clinical Chemistry, Complejo Hospitalario Universitario, Albacete, Spain, 6 Department of Pathology, Complejo
Hospitalario Universitario, Albacete, Spain
Abstract
The benefits of long-term peritoneal dialysis (PD) in patients with end-stage renal failure are short-lived due to structural
and functional changes in the peritoneal membrane. In this report, we provide evidence for the in vitro and in vivo
participation of the renin-angiotensin-aldosterone system (RAAS) in the signaling pathway leading to peritoneal fibrosis
during PD. Exposure to high-glucose PD fluids (PDFs) increases damage and fibrosis markers in both isolated rat peritoneal
mesothelial cells and in the peritoneum of rats after chronic dialysis. In both cases, the addition of the RAAS
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