adipose stromal cells amplify angiogenic signaling via the vegfmtorakt pathway in a murine hindlimb ischemia model a 3d multimodality imaging study脂肪基质细胞放大通过vegfmtorakt血管生成信号途径在小鼠后肢缺血模型3 d多峰性成像研究.pdfVIP

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adipose stromal cells amplify angiogenic signaling via the vegfmtorakt pathway in a murine hindlimb ischemia model a 3d multimodality imaging study脂肪基质细胞放大通过vegfmtorakt血管生成信号途径在小鼠后肢缺血模型3 d多峰性成像研究.pdf

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adipose stromal cells amplify angiogenic signaling via the vegfmtorakt pathway in a murine hindlimb ischemia model a 3d multimodality imaging study脂肪基质细胞放大通过vegfmtorakt血管生成信号途径在小鼠后肢缺血模型3 d多峰性成像研究

Adipose Stromal Cells Amplify Angiogenic Signaling via the VEGF/mTOR/Akt Pathway in a Murine Hindlimb Ischemia Model: A 3D Multimodality Imaging Study 1. 1. 2. 1 1 3 4 Weiwei Fan , Dongdong Sun , Junting Liu , Dong Liang , Yabin Wang , Kazim H. Narsinh , Yong Li , 1 2 2 1 Xing Qin , Jimin Liang , Jie Tian *, Feng Cao * 1 Department of Cardiology Molecular Imaging Program, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China, 2 Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi, China, 3 Department of Radiology Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United States of America, 4 Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China Abstract Although adipose-derived stromal cell (ADSC) transplantation has been demonstrated as a promising therapeutic strategy for peripheral arterial disease (PAD), the mechanism of action behind the observed therapeutic efficacy of ADSCs remains unclear. This study was designed to investigate the long-term outcome and therapeutic behavior of engrafted ADSCs in a murine hindlimb ischemia model using multimodality molecular imaging approaches. ADSCs (1.0 6107) were isolated from Tg(Fluc-egfp) mice which constitutively express dual-reporter firefly luciferase and enhanced green fluorescent protein (Fluc+ + Fluc+GFP+ -eGFP , mADSCs ), then intramuscularly injected into the hindlimb of BALB/c-nu mice after unilateral femoral artery ligation and excision. A