有哪些信誉好的足球投注网站adipose-derived stem cells stimulate regeneration of peripheral nerves bdnf secreted by these cells promotes nerve healing and axon growth de novo脂肪干细胞能刺激周围神经的再生由这些细胞分泌bdnf促进神经治疗和轴突生长的新创.pdfVIP
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adipose-derived stem cells stimulate regeneration of peripheral nerves bdnf secreted by these cells promotes nerve healing and axon growth de novo脂肪干细胞能刺激周围神经的再生由这些细胞分泌bdnf促进神经治疗和轴突生长的新创
Adipose-Derived Stem Cells Stimulate Regeneration of
Peripheral Nerves: BDNF Secreted by These Cells
Promotes Nerve Healing and Axon Growth De Novo
1 1 1 1 1
Tatiana Lopatina *, Natalia Kalinina , Maxim Karagyaur , Dmitry Stambolsky , Kseniya Rubina ,
2 2 1 1
Alexander Revischin , Galina Pavlova , Yelena Parfyonova , Vsevolod Tkachuk
1 Department of Biochemistry and Molecular Medicine, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia, 2 Institute of Gene
Biology, Russian Academy of Sciences, Moscow, Russia
Abstract
Transplantation of adipose-derived mesenchymal stem cells (ASCs) induces tissue regeneration by accelerating the growth
of blood vessels and nerve. However, mechanisms by which they accelerate the growth of nerve fibers are only partially
understood. We used transplantation of ASCs with subcutaneous matrigel implants (well-known in vivo model of
angiogenesis) and model of mice limb reinnervation to check the influence of ASC on nerve growth. Here we show that
ASCs stimulate the regeneration of nerves in innervated mice’s limbs and induce axon growth in subcutaneous matrigel
implants. To investigate the mechanism of this action we analyzed different properties of these cells and showed that they
express numerous genes of neurotrophins and extracellular matrix proteins required for the nerve growth and myelination.
Induction of neural differentiation of ASCs enhances production of brain-derived neurotrophic factor (BDNF) as well as
ability of these cells to induce nerve fiber growth. BDNF neutralizing antibodies abrogated the
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