有哪些信誉好的足球投注网站adjuvant effect of killed propionibacterium acnes on mouse peritoneal b-1 lymphocytes and their early phagocyte differentiation佐剂效应杀害丙酸菌属曼秀雷敦小鼠腹膜b淋巴细胞和吞噬细胞分化.pdfVIP
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adjuvant effect of killed propionibacterium acnes on mouse peritoneal b-1 lymphocytes and their early phagocyte differentiation佐剂效应杀害丙酸菌属曼秀雷敦小鼠腹膜b淋巴细胞和吞噬细胞分化
Adjuvant Effect of Killed Propionibacterium acnes on
Mouse Peritoneal B-1 Lymphocytes and Their Early
Phagocyte Differentiation
1 ˜ 1,2 1
Juliana Sekeres Mussalem , Carla Cristina Squaiella-Baptistao , Daniela Teixeira , Tatiana
1 1 1 1 ´ 1
Mina Yendo , Felipe Garutti Thies , Ana Flavia Popi , Mario Mariano , Ieda Longo-Maugeri *
˜ ˜
1 Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo – Escola Paulista de Medicina, Sao Paulo,
´ ´ ˜
Brasil, 2 Laboratorio de Imunoquımica, Instituto Butantan, Sao Paulo, Brasil
Abstract
B-1 lymphocytes are the predominant cells in mouse peritoneal cavity. They express macrophage and lymphocyte markers
and are divided into B-1a, B-1b and B-1c subtypes. The role of B-1 cells is not completely clear, but they are responsible for
natural IgM production and seem to play a regulatory role. An enriched B-1b cell population can be obtained from non-
adherent peritoneal cell cultures, and we have previously demonstrated that these cells undergo differentiation to acquire a
mononuclear phagocyte phenotype upon attachment to the substrate in vitro. Nevertheless, the B-1 cell response to
antigens or adjuvants has been poorly investigated. Because killed Propionibacterium acnes exhibits immunomo
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