adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress肥胖与钝化心血管、神经内分泌和认知反应严重的精神压力.pdfVIP
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adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress肥胖与钝化心血管、神经内分泌和认知反应严重的精神压力
Adiposity Is Associated with Blunted Cardiovascular,
Neuroendocrine and Cognitive Responses to Acute
Mental Stress
1 1 2,3 1 1
Alexander Jones *, Merlin R. McMillan , Russell W. Jones , Grzegorz T. Kowalik , Jennifer A. Steeden ,
4 5 1 1
John E. Deanfield , Jens C. Pruessner , Andrew M. Taylor , Vivek Muthurangu
1 Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, United Kingdom, 2 Chorleywood Health Centre, Chorleywood, United Kingdom,
3 Department of Information Systems and Computing, Brunel University, Uxbridge, United Kingdom, 4 Centre for Cardiovascular Prevention Outcomes, UCL Institute of
Cardiovascular Science, London, United Kingdom, 5 Douglas Institute, Department of Psychiatry, McGill University, Montreal, Canada
Abstract
Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear.
Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to
conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses and of fat
distribution allow accurate assessment of associations between adiposity and stress responsiveness. We measured
responses to the Montreal Imaging Stress Task in healthy men (N = 43) and women (N = 45) with a wide range of BMIs. Heart
rate (HR) and blood pressure (BP) measures were used with novel magnetic resonance measures of stroke volume (SV),
cardiac output (CO), total peripheral resistance (TPR) a
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