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a two-stage model for lipid modulation of the activity of integral membrane proteins脂质调制的两阶段模型的整合膜蛋白的活性
A Two-Stage Model for Lipid Modulation of the Activity
of Integral Membrane Proteins
´ 1,2 1,3 2 ´ 1
Martın M. Dodes Traian , Diego I. Cattoni , Valeria Levi , F. Luis Gonzalez Flecha *
´ ´ ´ ´
1 Laboratorio de Biofısica Molecular – Instituto de Quımica y Fisicoquımica Biologicas, Universidad de Buenos Aires - CONICET, Buenos Aires, Argentina, 2 Laboratorio de
´ ´ ´
Dinamica Intracelular– Departamento de Quımica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina, 3 Centre de
´
Biochimie Structurale, INSERM U554, CNRS UMR 5048, Universite de Montpellier 1 and 2, Montpellier, France
Abstract
Lipid-protein interactions play an essential role in the regulation of biological function of integral membrane proteins;
however, the underlying molecular mechanisms are not fully understood. Here we explore the modulation by
phospholipids of the enzymatic activity of the plasma membrane calcium pump reconstituted in detergent-phospholipid
mixed micelles of variable composition. The presence of increasing quantities of phospholipids in the micelles produced a
cooperative increase in the ATPase activity of the enzyme. This activation effect was reversible and depended on the
phospholipid/detergent ratio and not on the total lipid concentration. Enzyme activation was accompanied by a small
structural change at the transmembrane domain reported by 1-aniline-8-naphtalenesulfonate fluorescence. In addition, the
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