a scalable system for production of functional pancreatic progenitors from human embryonic stem cells一个可伸缩系统生产功能性胰腺祖细胞从人类胚胎干细胞.pdfVIP
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a scalable system for production of functional pancreatic progenitors from human embryonic stem cells一个可伸缩系统生产功能性胰腺祖细胞从人类胚胎干细胞
A Scalable System for Production of Functional
Pancreatic Progenitors from Human Embryonic Stem
Cells
1 2 2 2 2
Thomas C. Schulz *, Holly Y. Young , Alan D. Agulnick , M. Josephine Babin , Emmanuel E. Baetge ,
2 2 2 2 2
Anne G. Bang , Anindita Bhoumik , Igor Cepa , Rosemary M. Cesario , Carl Haakmeester ,
2 2 2 2 3
Kuniko Kadoya , Jonathan R. Kelly , Justin Kerr , Laura A. Martinson , Amanda B. McLean ,
2 2 2 2 1 1
Mark A. Moorman , Janice K. Payne , Mike Richardson , Kelly G. Ross , Eric S. Sherrer , Xuehong Song ,
2 2 2 2 2
Alistair Z. Wilson , Eugene P. Brandon , Chad E. Green , Evert J. Kroon , Olivia G. Kelly ,
Kevin A. D’Amour2, Allan J. Robins1,2
1Viacyte, Inc., Athens, Georgia, United States of America, 2 Viacyte, Inc., San Diego, California, United States of America, 3 Department of Biochemistry and Molecular
Biology, University of Georgia, Athens, Georgia, United States of America
Abstract
Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-
of-principle concepts into a scalable, controlled, and regulated cell manufacturing process. We have previously
demonstrated that hESC can be directe
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