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a screen for rna-binding proteins in yeast indicates dual functions for many enzymes屏幕rna结合蛋白在酵母表明许多酶双重功能
A Screen for RNA-Binding Proteins in Yeast Indicates
Dual Functions for Many Enzymes
1 2,3 2¤ ´ 1
Tanja Scherrer , Nitish Mittal , Sarath Chandra Janga , Andre P. Gerber *
1 Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland, 2 Medical Research Council (MRC) Laboratory of
Molecular Biology, Cambridge, United Kingdom, 3 Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Punjab, India
Abstract
Hundreds of RNA-binding proteins (RBPs) control diverse aspects of post-transcriptional gene regulation. To identify novel
and unconventional RBPs, we probed high-density protein microarrays with fluorescently labeled RNA and selected 200
proteins that reproducibly interacted with different types of RNA from budding yeast Saccharomyces cerevisiae. Surprisingly,
more than half of these proteins represent previously known enzymes, many of them acting in metabolism, providing
opportunities to directly connect intermediary metabolism with posttranscriptional gene regulation. We mapped the RNA
targets for 13 proteins identified in this screen and found that they were associated with distinct groups of mRNAs, some of
them coding for functionally related proteins. We also found that overexpression of the enzyme Map1 negatively affects the
expression of experimentally defined mRNA targets. Our results suggest that many proteins may associate with mRNAs and
possibly control their fates, providing dense connections between different layers of cellular regulation.
Citation: Scherrer T, Mittal N, Janga SC, Gerber AP (2010) A Screen for RNA-Binding Proteins in Yeast Indicates Dual Functions for Many Enzymes. PLoS ONE 5(11):
e15499. doi:10
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