有哪些信誉好的足球投注网站a toxoplasma morn1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis弓形虫morn1零突变发生重复分歧但在基底装配缺陷,apicoplast分裂和胞质分裂.pdfVIP
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a toxoplasma morn1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis弓形虫morn1零突变发生重复分歧但在基底装配缺陷,apicoplast分裂和胞质分裂
A Toxoplasma MORN1 Null Mutant Undergoes Repeated
Divisions but Is Defective in Basal Assembly, Apicoplast
Division and Cytokinesis
1 2 1 1 1¤
Alexander Lorestani , Lilach Sheiner , Kevin Yang , Seth D. Robertson , Nivedita Sahoo , Carrie F.
2 3 2 1
Brooks , David J. P. Ferguson , Boris Striepen , Marc-Jan Gubbels *
1 Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States of America, 2 Department of Cellular Biology and Center for Tropical and Emerging
Global Diseases, University of Georgia, Athens, Georgia, United States of America, 3 Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe
Hospital, Oxford, United Kingdom
Abstract
The membrane occupation and recognition nexus protein 1 (MORN1) is highly conserved among apicomplexan parasites
and is associated with several structures that have a role in cell division. Here we dissected the role of MORN1 using the
relatively simple budding process of Toxoplasma gondii as a model. Ablation of MORN1 in a conditional null mutant resulted
in pronounced defects suggesting a central role for MORN1 in apicoplast segregation and in daughter cell budding. Lack of
MORN1 resulted in double-headed parasites. These Janus-headed parasites form two complete apical complexes but fail to
assemble a basal complex. Moreover, these parasites were capable of undergoing several more budding rounds resulting in
the formation of up to 16-headed parasites conjoined at the basal end. Despite this segregation defect, the mother’s
cytoskeleton was completely disassembled in every budding round. Overall this argues that s
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