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a tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancertri-marker扩散指数预测生化为前列腺癌手术后复发
A Tri-Marker Proliferation Index Predicts Biochemical
Recurrence after Surgery for Prostate Cancer
1. 2. 3,4. 3 1
Sameer Malhotra , Jacques Lapointe , Keyan Salari , John P. Higgins , Michelle Ferrari , Kelli
3 3 1 3
Montgomery , Matt van de Rijn , James D. Brooks * , Jonathan R. Pollack *
1 Department of Urology, Stanford University, Stanford, California, United States of America, 2 Department of Surgery, Urology Division, McGill University, Montreal,
Quebec, Canada, 3 Department of Pathology, Stanford University, Stanford, California, United States of America, 4 Department of Genetics, Stanford University, Stanford,
California, United States of America
Abstract
Prostate cancer exhibits tremendous variability in clinical behavior, ranging from indolent to lethal disease. Better
prognostic markers are needed to stratify patients for appropriately aggressive therapy. By expression profiling, we can
identify a proliferation signature variably expressed in prostate cancers. Here, we asked whether one or more tissue
biomarkers might capture that information, and provide prognostic utility. We assayed three proliferation signature genes:
MKI67 (Ki-67; also a classic proliferation biomarker), TOP2A (DNA topoisomerase II, alpha), and E2F1 (E2F transcription factor
1). Immunohistochemical staining was evaluable on 139 radical prostatectomy cases (in tissue microarray format), with a
median clinical follow-up of eight years. Each of the three proliferation markers was by itself prognostic. Notably,
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